國立嘉義大學

                    

姓名 聯絡電話 E-MAIL

簡啟民CHIEN CHING-MING 分機:7968 辦公室:A17-404B Mail:cmchien@mail.ncyu.edu.tw

                                                                                                          

主要學歷 

現職及與專長相關經歷 

專長 

教授課目

研究計畫(近三年)

• 2022年-利用結構生物學與生物化學方法開發新型哌嗪硫脲化合物之專一性DNA結合藥物

        (中華民國國科會)-計畫主持人(三年期)

• 2022年-新型釕金屬錯合物之抗癌活性探討與DNA結合能力評估

(長榮大學新進教師) -計畫主持人

• 2021年-透過生物活性與生物物理工具探討新穎性Piperazine衍生物對抗藥性之癌症作用機制

        (長榮大學薪傳計畫) –共同主持人

• 2020年-探討釕金屬錯合物之核酸鍵結機制與癌症治療應用

(台南新樓醫院計畫) –共同主持人

榮譽事項

• 2023年- 111學年校級教學特優教師 (長榮大學)

• 2022年- 110學年院級績優導師 (長榮大學) 

• 2021年- 最佳論文壁報獎 (中華民國生物醫學工程學會)

• 2020年- 第十七屆國家新創獎 (創新防疫科技類)

• 2018年- 壁報競賽佳作獎 (中華民國生醫材料及藥物制放學會)

• 2015年- Excellent Poster Award  (高醫國際幹細胞研討會) 

獎勵及指導學生獲獎

• 2024年大專生研究計畫通過-詹博羽-利用腸病毒家族3C蛋白酶的高度保留區域進行藥物開發

策略之電腦輔助設計研究 

• 2024年 中國化學會高雄分會-壁報競賽無機組優選-專題學生:陳姿妤

• 2023年 長榮大學程式設計跨域創意競賽銀獎-指導老師

• 2023年 Outstanding Prize Award of Student Poster-(台灣生物無機化學研討會)-專題學生:王昕

• 2023年 Bio-Kaohsiung生命科學研究成果壁報競賽-學士班組第一名-專題學生:詹博羽

• 2023年 Bio-Kaohsiung生命科學研究成果壁報競賽-學士班組第三名-專題學生:陳姿妤

• 2022年 Bio-Kaohsiung生命科學研究成果壁報競賽-學士班組佳作-專題學生:楊子欣

• 2022年大專生研究計畫通過-楊子欣-利用硫酸乙醯肝素與新冠病毒棘蛋白受體結合區域作為藥

                                物開發策略之電腦輔助藥物設計研究

• 2021年大專生研究計畫通過-陳子瑋-探討Piperazine衍生物對大腸直腸癌之抗癌活性評估

指導專題學生論文

• 2022年-楊子欣-學士-利用硫酸乙醯肝素與新冠病毒棘蛋白受體結合區域作為藥物開發策略之電腦輔助藥物設計研究

• 2022年-陳子瑋-學士-新型哌嗪衍生物作為小分子藥物設計合成: 體外抗癌、電腦模擬之初步研究

• 2021年-陳佳穎-學士-哌嗪衍生物(Piperazine derivative)對HCT116+ch3大腸直腸癌細胞株凋亡機制之研究

受邀演講 Invited speaker:

• 2022年- 台灣生物無機化學研討會-主題:DNA binding model and in vitro cytotoxic activity for 

                                   Ru(η6-p-cymene) complexes bearing with pyridine ligands 

• 2022 年- 國立臺灣海洋大學     -主題:Protein structure analysis technology -Structure-based Drug 

                                   development strategy

報章發表著作

• 2022/05/03-SMC台灣科技媒體中心-living with COVID-19，新冠肺炎口服藥現況

• 2022/02/15-SMC台灣科技媒體中心-研究:口服抗病毒藥可降低新冠傳播風險

專利

• 2014年-含二吡啶并啡并配位基之銅錯合物-發明者:林助傑,簡啟民,邱進益,賴盈如,許焯涵

      -專利証號:I464174

學術期刊論文發表成果

Journal paper:年(2024-2018)

1. Zi-Sin Yang, Tzong-Shiun Li, Huang-Yu Sung, Cheng-Chung Chang, and Ching-Ming Chien*, (2024, Feb) Targeting the Receptor Binding Domain and Heparan Sulfate Binding for Antiviral Drug Development against SARS-CoV-2 Variants, Scientific Report ,2024, 14 (1), 2753. 

2. Chi Cheng, Sheng-Kai Hsu, Yen-Chun Chen, Wangta Liu, En-De Shu, Ching-Ming Chien, Chien-Chih Chiu, Wen-Tsan Chang, (2024, Jun). Burning down the house: Pyroptosis in the tumor microenvironment of hepatocellular carcinoma, Life Sciences, 15, 347, 2024, 122627.

3. Kuei-Ying Wang, Ching-Ming Chien, Huan-Fang Lee, Yohana Yobelina, (2023, Nov) The mediation of health-promoting lifestyle on self-perceived health status and quality of life among nurses: a cross-sectional study, BMC Nursing, vol. 28, 22(1), Nov 2023, 447.  

4. Roshan Satange, Shih-Hao Kao, Ching-Ming Chien, Shan-Ho Chou, Chi-Chien Lin, Stephen Neidle, and Ming-Hon Hou, (2022, Aug). Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism, Nucleic Acids Research, 2022 Aug 26;50(15):8867-8881. 

5. Penki V.S. Sashankh, Dorothy Priyanka Dorairaja, Jia-Ying Chen, Yu-Lan Chang, Kuldeep Chan, Ramasamy Karvembu, Ching-Ming Chien*, Sodio C.N.Hsu*, (2022, Aug). Synthesis, in silico and in vitro studies of piperazinyl thiourea derivatives as apoptosis inducer for the treatment of colorectal carcinoma, Journal of Molecular Structure, Vol.1262, Aug 2022, pp.133086. 

6. Rong-Kai Lin, Parthiban Venkatesan, Chao-Hsuan Yeh, Ching-Ming Chien, Te-Shan Lin, Chi-Chen Lin, Chu-Chieh Lin, Ping-Shan Lai, (2022, Apr) Effective topical treatments using innovative NNO-tridentate vanadium(IV) complexes-mediated photodynamic therapy in a psoriasis-like mouse model, Journal of Materials Chemistry B, Vol.10, Jun 2022, pp. 4759-4770. 

7. Shan-Meng Lin, Shih-Chao Lin, Jia-Ning Hsu, Chung-Ke Chang, Ching-Ming Chien, Yong-Sheng Wang, Hung-Yi Wu, U-Ser Jeng, Kylene Kehn-Hall, Ming-Hon Hou (2020, Mar). Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. Journal of Medicinal Chemistry, 26;63(6):3131-3141.

8. Ching-Ming Chien, Pei-Ching Wu, Roshan Satange, Cheng-Chung Chang, Zi-Lun Lai, Lauren D Hagler, Steven C Zimmerman, Ming-Hon Hou (2020, Jun). Structural Basis for Targeting T:T Mismatch with Triaminotriazine-AcridineConjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA. Journal of the American Chemical Society, 142, 25, 11165-11172.

9. Chen RF, Wang CT, Chen YH, Chien CM, Lin SD, Lai CS, Wang CJ, Kuo YR. (2019, May). Hyaluronic Acid-Povidone-Iodine Compound Facilitates Diabetic Wound Healing in a Streptozotocin-Induced Diabetes Rodent Model. Plast Reconstr Surg, 143(5):1371-1382.

10. Huang YC, Haribabu J, Chien CM, Sabapathi G, Chou CK, Karvembu R, Venuvanalingam P, Ching WM, Tsai ML, Hsu SCN (2019, May). Half-sandwich Ru(η6-p-cymene) complexes featuring pyrazole appended ligands: Synthesis, DNA binding and in vitro cytotoxicity. J Inorg Biochem, 194:74-84. 

11. Ching-Ming Chien, Juan-Cheng Yang, Pin-Hsuan Wu, Chang-Yi Wu, Guan-Yu Chenc, Yang-Chang Wue, Chon-Kit Choua, Chih-Hua Tsengg, Yeh-Long Chenh, Li- Fang Wang, Chien-Chih Chiu (2019, Feb). Phytochemical 1 Naphtho[1,2-b] furan-4,5-dione Induced Topoisomerase II-mediated DNA Damage Response in Human Non-small-Cell Lung Cancer. Phytomedicine, 15;54:109-119. 

12. Chon-Kit Chou, Wangta Liu,Yu-Jie Hong, Hans-Uwe Dahms, Chen-Hao Chiu, Wen-Tsan Chang, Ching-Ming Chien, Chia-Hung Yen, Yuan-Bin Cheng and Chien-Chih Chiu (2018, Jun). Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. International Journal of Molecular Sciences, 19(7), 1832. 

13. Yur-Ren Kuo*, Chien-Chang Chen, Yen-Chou Chen, Ching-Ming Chien, (2017, Aug). Recipient Adipose-derived Stem Cells Enhance Recipient Cell Engraftment and Prolong Allotransplant Survival in a Miniature Swine Hind-limb Model. Cell Transplantation , 26(8):1418-1427. 

14. Ching-Ming Chien, Yung-Wei Chen, Chien-Chang Chen, Yi-Chia Wu, Shu-Hung Huang, Su-Shin Lee, Cheng-Sheng Lai, Sin-Daw Lin, Ching-Jen Wang, Yur-Ren Kuo*, (2016, Nov). Adipose-Derived Stem Cell Modulation of T-Cell Regulation Correlates with Heme Oxgenase-1 Pathway Changes. Plastic and Reconstructive Surgery, (2016), 138(5):1015-1023. 

15. Chia-Hung Kuo, Jer-An Lin, Ching-Ming Chien, Chang-Han Tsai, Yung-Chuan Liuc, Chwen-Jen Shieh*, (2016, Jul) Formation of amide bond catalyzed by lipase in aqueous phase forpeptide synthesis Journal of Molecular Catalysis B: Enzymatic, (2016), 129:15-20. 

16. Yur-Ren Kuo*, Ching-Ming Chien, Ming-Jen Kuo, Feng-Sheng Wang, Eng-Yen Huang, (2016, Jan) Endothelin-1 Expression Associated with Lipid Peroxidation and NF-κB Activation in Type II Diabetes Mellitus Patients with Angiopathy and Limb Amputation. Plastic and Reconstructive Surgery, (2016), 137(1):187-195. 

17. Rong-Kai Lin, Cho-Han Hsu, Chin-I Chiu, Ying-Ju Lai, Feng-Jie Lai, Ching-Ming Chien*, Chu-Chieh Lin*. (2014, Sep) Syntheses, Structures and Anticancer Activity of NNO-Tridentate Schiff Base Copper(II) Complexes. Journal of the Chinese Chemical Society, (2014), 61, 1333-1340. 

18. Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng,Yeh-Long Chen,Long-Sen Chang,and Shinne-Ren Lin*, (2014, May). Furano-1,2-Naphthoquinone Inhibits Src and PI3K/Akt Signaling Pathways in Ca9-22 Human Oral Squamous Carcinoma Cells. Integrative Cancer Therapies, (2014), 13(3):NP18-28. 

19. Kuei-Li Lin, Ching-Ming Chien, Chi-Ying Hsieh, Pei-Chien Tsai, Long-Sen Chang, Shinne-Ren Lin*, (2012, Jan) Antimetastatic potential of cardiotoxin III involves inactivation of PI3K/Akt and p38 MAPK signaling pathways in human breast cancer MDA-MB-231 cells. Life Sciences, (2012), 90(1-2):54-65. 

20. Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2010, Dec). Furano-1,2-naphthoquinone inhibits EGFR signaling associated with G2/M cell cycle arrest and apoptosis in A549 cells. Cell Biochemistry and Function, (2010), 2;28(8):695-705. 

21. Ching-Ming Chien, Shang-Yu Chang, Kuei-Li Lin, Chien-Chih Chiu, Long-Sen Chang, Shinne-Ren Lin*,  (2010, Sep). Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells. Toxicon, (2010), 56(4):508-520. 

22. Jung-Chen Su, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Lin*, (2010, Aug). Concomitant inactivation of the epidermal growth factor receptor, phosphatidylinositol 3-kinase/Akt and Janus tyrosine kinase 2/signal transducer and activator of transcription 3 signalling pathways in cardiotoxin III-treated A549 cells. Clinical and Experimental Pharmacology and Physiology, (2010), 37(8):833-40. 

23. Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2010, Feb). Naphtho[1,2-b]furan-4,5-dione induces apoptosis and S-phase arrest of MDA-MB-231 cells through JNK and ERK signaling activation. Toxicology in Vitro, (2010), 24(1):61-70. 

24. Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Pei-Wen Chuang, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2010, Jun). Naphtho[1,2-b]furan-4,5-dione induces apoptosis of oral squamous cell carcinoma: involvement of EGF receptor/PI3K/Akt signaling pathway. European Journal of Pharmacology, (2010), 636(1-3):52-58. 

25. Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Pei-Wen Chuang, Long-Sen Chang, Shinne-Ren Lin*, (2010, Jun). Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells. Toxicon, (2010), 55(7):1263-1273. 

26. Kuei-Li Lin, Jung-Chen Su, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2010, Jun). Naphtho[1,2-b]furan-4,5-dione disrupts Janus kinase-2 and induces apoptosis in breast cancer MDA-MB-231 cells.Toxicology in Vitro, (2010), 24(4):1158-1267. 

27. Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Chih-Hua Tseng, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2010, Jan). Naphtho[1,2-b]furan-4,5-dione inactivates EGFR and PI3K/Akt signaling pathways in human lung adenocarcinoma A549 cells. Life Sciences, (2010), 86(5-6):207-213. 

28. Sheng-Huei Yang, Ching-Ming Chien, Jung-Chen Su, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2009 Dec). Novel indoloquinoline derivative, IQDMA, inhibits STAT5 signaling associated with apoptosis in K562 cells. Journal of Biochemical and Molecular Toxicology, (2008), 22(6):396-404. 

29. Yu-Sheng Tu, Tsai-Hui Duh, Chen-Yi Tseng, Ying-Ting Lin, Yu-Hsiang Lo, Yi-Ling Hu, Chen-Hung Chen, Ching-Ming Chien, Sheng-Huei Yang, Shinne-Ren Lin, Shyh-Chyun Yang, Ming-Jung Wu*, (2009 Nov). 1-(2-((Z)-6-(2-(Trifluoromethyl)phenyl)hexa-3-en-1,5-diynyl)phenyl)piperidin -2-one as a new potent apoptosis agent. Bioorganic & Medicinal Chemistry., (2009), 17(21):7412-7417. 

30. Ching-Ming Chien, Kuei-Li Lin, Jung-Chen Su, Long-Sen Chang, Shinne-Ren Lin*, (2009 Oct). Inactivation of epidermal growth factor receptor and downstream pathways in oral squamous cell carcinoma Ca9-22 cells by cardiotoxin III from Naja naja atra. Journal of Natural Products, (2009), 72(10):1735-1740. 

31. Jung-Chen Su, Kuei-Li Lin, Ching-Ming Chien, Chih-Ming Lu, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2009 Sep). Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sciences., (2009), 85(13-14):505-516. 

32. Chien-Chih Chiu, Kuei-Li Lin, Ching-Ming Chien, Long-Sen Chang, Shinne-Ren Lin*, (2009). Effects of cardiotoxin III on NF-kappaB function, proliferation, and apoptosis in human breast MCF-7 cancer cells. Oncology Research, (2009), 17(7):311-321. 

33. Ching-Ming Chien, Sheng-Huei Yang, Kuei-Li Lin, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2008 Oct). Novel indoloquinoline derivative, IQDMA, suppresses STAT5 phosphorylation and induces apoptosis in HL-60 cells. Chemico-Biological Interactions, (2008), 176, 40-47.

34. Ching-Ming Chien, Sheng-Huei Yang, Long-Sen Chang, Shinne-Ren Lin*, (2008 Aug). Involvement of both endoplasmic reticulum- and mitochondria-dependent pathways in cardiotoxin III-induced apoptosis in HL-60 cells. Clinical and Experimental Pharmacology and Physiology, (2008), 35,1059-1064. 

35. Sheng-Huei Yang, Zchong-Zcho Wu, Ching-Ming Chien, Yu-Hsiang Lo, Ming-Jung Wu, Long-Sen Chang, Shinne-Ren Lin*, (2008 Aug). JNK and ERK mitogen-activated protein kinases mediate THDA-induced apoptosis in K562 cells. Cell Biology and Toxicology, (2008), 24(4):291-302. 

36. Sheng-Huei Yang, Ching-Ming Chien, Long-Sen Chang, Shinne-Ren Lin*, (2008 Jun). Cardiotoxin III-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation in K562 cells. Journal of Biochemical and Molecular Toxicology, (2008), 22(3):209-18. 

37. Ching-Ming Chien, Sheng-Huei Yang, Chun-Chieh Yang, Long-Sen Chang, Shinne-Ren Lin*, (2008 Jun). Cardiotoxin III induces c-jun N-terminal kinase-dependent apoptosis in HL-60 human leukaemia cells. Cell Biochemistry and Function, (2008), 26, 111-118. 

38. Sheng-Huei Yang, Ching-Ming Chien, Chih-Ming Lu, Yeh-Long Chen, Long-Sen Chang, Shinne-Ren Lin*, (2007 Oct). Involvement of c-Jun N-terminal kinase in G2/M arrest and FasL-mediated apoptosis induced by a novel indoloquinoline derivative, IQDMA, in K562 cells. Leukemia Research, (2007), 31(10):1413-20.

 

39. Sheng-Huei Yang, Ching-Ming Chien, Long-Sen Chang, Shinne-Ren Lin*, (2007 Jun). Involvement of c-jun N-terminal kinase in G2/M arrest and caspase-mediated apoptosis induced by cardiotoxin III (Naja naja atra) in K562 leukemia cells. Toxicon, (2007), 49(7):966-74. 

40. Sheng-Huei Yang, Chien-Hsun Tsai, Mei-Chin Lu, Yung-Ning Yang, Ching-Ming Chien, Sheng-Fung Lin, Shinne-Ren Lin*, (2007 Jun). Effects of cardiotoxin III on expression of genes and proteins related to G2/M arrest and apoptosis in K562 cells. Molecular and Cellular Biochemistry., (2007), 300(1-2):185-90. 

41. Yu-Jhang Lu, Sheng-Huei Yang, Ching-Ming Chien, Yi-Hsiung Lin, Xiu-Wei Hu, Zchong-Zcho Wu, Ming-Jung Wu, Shinne-Ren Lin*, (2007 Feb). Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDB, in chronic myeloid leukemia (HL-60) cells. Toxicology in Vitro., (2007), 21(1):90-8.

42. Yi-Hsiung Lin, Sheng-Huei Yang, Ching-Ming Chien, Xiu-Wei Hu, Ying-Hui Huang, Chih-Ming Lu, Yeh-Long Chen, Shinne-Ren Lin*, (2007 Dec). Induction of G2/M phase arrest and apoptosis by a novel indoloquinoline derivative, IQDMA, in K562 cells. Drug Development Research, (2006), 67(9):743-51. 

43. Xiu-Wei Hu, Ching-Ming Chien, Sheng-Huei Yang, Yi-Hsiung Lin, Chih-Ming Lu, Yeh-Long Chen, Shinne-Ren Lin*, (2006 Nov). A novel indoloquinoline derivative, IQDMA, induces S-phase arrest and apoptosis in promyelocytic leukemia HL-60 cells. Cell Biology and Toxicology, (2006), 22(6):417-27. 

44. Zchong-Zcho Wu, Ching-Ming Chien, Sheng-Huei Yang, Yi-Hsiung Lin, Xiu-Wei Hu, Yu-Jhang Lu, Ming-Jung Wu, Shinne-Ren Lin*, (2006 Nov). Induction of G2/M phase arrest and apoptosis by a novel enediyne derivative, THDA, in chronic myeloid leukemia (K562) cells. Molecular and Cellular Biochemistry, (2006), 292(1-2):99-105. 

45. Sheng-Huei Yang, Ching-Ming Chien, Mei-Chin Lu, Yi-Hsiung Lin, Xiu-Wei Hu, Shinne-Ren Lin*, (2006 Aug). Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-XL involved in cardiotoxin III-induced apoptosis in K562 cells. Experimental & Molecular Medicine, (2006), 38(4):435-44. 

46. Chien-Hsun Tsai, Sheng-Huei Yang, Ching-Ming Chien, Mei-Chin Lu, Chao-Sheng Lo, Yi-Hsiung Lin, Xiu-Wei Hu, Shinne-Ren Lin*, (2006 Mar). Mechanisms of cardiotoxin lll-induced apoptosis in human colorectal cancer colo205 cells. Clinical and Experimental Pharmacology and Physiology, (2006), 33(3):177-82. 

中文期刊論文:

1. 林珊夢,簡啟民, 黃瀞瑩, 孫心慈, 侯明宏（2020年12月）。標靶核殼蛋白非典型蛋白質間交介面開發抗冠狀病毒藥物。化學，78(4)，333-342。

Conference paper(研討會論文):

1. Xin Wang, Tzu-Yu Chen, Yin-Hsuan Sun, Sodio C.N.Hsu , Ching-Ming Chien*. (2023 Dec). Ru(η6-p-cymene) complexes bearing with ethylenediamine ligand induced apoptosis in MDA-MB-231 cells through PI3K/Akt axis, 2023 Taiwan Bioinorganic Chemistry Society, Dec. 2023, Taitung, Taiwan.

2. Yi-Chen Huang, Tzu-Yu Chen, Po-Yu Chan, Sodio C.N.Hsu, Ching-Ming Chien*. (2023 Jul). Cytotoxic Effects of Piperazinyl Thiourea Derivative P3 on Cisplatin-Resistant Colon Cancer Cells, Nucleic Acids Prospect and Therapeutic Applications, Jul. 2023, Taichung, Taiwan.

3. Po-Yu Chan, Zi-Sin Yang, Shih-Chao Lin, Sodio C. N. Hsu, Ching-Ming Chien* (2023 Mar) ,'The piperazinyl thiourea derivatives act as 3C protease inhibitors of human Enterovirus 71. 2023 Chemistry National Meeting, National University of Kaohsiung, Taiwan

4. Tzu-Yu Chen, Yi-Chen Huang, Yi-Xuan Lin, Xin Wang, Tzu-Wei Chen, Zi-Sin Yang, Sodio C.N.Hsu, Ching-Ming Chien*.(2023 Mar) ,The piperazine thiourea derivative induced c-MYC mediated apoptosis in cisplatin-resistant colon cancer., 2023 Chemistry National Meeting, National University of Kaohsiung, Taiwan

5. Ching-Ming Chien, Dorothy Priyanka Dorairaj, Jia-Ying Chen, Sodio C.N. Hsu. (2022, Aug). Discovery of piperazinyl thiourea derivatives with DNA binding affinity and induce apoptosis for colorectal cancer. INDIA-EMBO Lecture Course. Functional nucleic acids: Recent landscapes and therapeutic applications, Faridabad, India.

6. Jia-Ying Chen, Jia-Rong Tsai, Tzu-Wei Chen, Zi-Xin Yang, Tzu-Yu Chen, Chien-Chih Chiu, Sodio C.N.Hsu, Ching-Ming Chien* (2022, Mar). The novel piperazine thiourea derivative with DNA binding affinity induces MAPK mediated mitochondrial apoptosis in colorectal cancer cells., The 36th The Taiwan Society of Biochemistry and Molecular Biology, Taipei, Taiwan. 

7. Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu (2021, Dec). Phytochemical naphtho[1,2-b] furan-4,5 dione in non-toxic dose inhibit VEGF-mediated cell migration and invasion in human non-small-cell lung cancer. Asia Pacific Federation of Pharmacologists 2021, Taipei. 

8. 楊子欣，侯明宏，簡啟民*。（2021年11月）探討硫酸乙醯肝素與新冠病毒棘蛋白受體結合區作為抗病毒藥物開發位點之 In silico 研究 : 以台灣清冠一號為例。2021 Annual Meeting of Taiwanese Society of Biomedical Engineering，台中。

9. Ching-Ming Chien, Jia-Ning Hsu, and Ming-Hon Hou (2018, May). Structure Modeling of N-terminal domain of Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and its Further Validation by X-ray Crystallization. The 23rd Biophysics Conference, Taichung, Taiwan. 

10. Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu (2018, Mar). NFD induced DNA damage-mediated-apoptosis in human non-small cell lung cancer via modulating topoisomerase II and NF-κB activity. The 33rd Joint Annual Conference of Biomedical Science, Taipei, Taiwan. 

11. Ching-Ming Chien, Pin-Hsuan Wu, Yeh-Long Chen, Chien-Chih Chiu (2018, Mar). Naphtha[1,2-b] furan-4,5-dione exerts antitumor activity in human non-small cell lung cancer through regulating topoisomerase II activity and DNA damage response. 2018 Biomaterials and Controlled Releases Society & Controlled Release Society, Kaohsiung, Taiwan. 

12. I-Hao Chen, Ching-Ming Chien, Chun-Ting Wang, Chih-Ling Huang, Chih-Kuang Wang and Yur-Ren Kuo (2018, Jan). Development for wound dressing with powder dosage form by chitosan and gelatin hydrogel. The 8th International Conference on Advanced Materials Research, Fukuoka, Japan.

13. Ching-Ming Chien, Chi-Wei Hong, Chun-Ting Wang, Yun-Ting Li, Yur-Ren Kuo (2017, Mar). The role of Heme Oxgenase-1 in Adipose-Derived Stem Cell Modulated T-Cell. 76th General Scientific Meeting, Taiwan Surgical Association. Taipei.

14. Chi-Wei Hong, Ching-Ming Chien, Yur-Ren Kuo (2017, Mar). Adipose-Derived Stem Cell Modulation of B-Cell Regulation Correlates with TGF-beta and IL-10 related pathway. 76th General Scientific Meeting, Taiwan Surgical Association., Taipei.

15. Chun-Ting Wang, Ching-Ming Chien, Chi-Wei Hong, Yun-Ting Li, Pei-Ling Yen, Yur-Ren Kuo (2017, Mar). The bio-mechanisms of hypoxia- induced stem cells-preconditioned medium enhance diabetic wound healing in a STZ-induced diabetic rat model. 76th General Scientific Meeting, Taiwan Surgical Association., Taipei. 

16. Pei-Ling Yen, Ching-Ming Chien, Yur-Ren Kuo (2017, Mar). Microarray Analysis of MicroRNA Expressions in Adipose-derived Stem Cells Modulated Allotransplant Rejection in a Rodent Hind-Limb Model. 76th General Scientific Meeting, Taiwan Surgical Association., Taipei. 

17. Yu-Chi Wang, Ching-Ming Chien, Yur-Ren Kuo (2017, Mar). Adipose-derived Stem Cells Modulation of Dendritic Cells Maturation Is Associated with Notch Activation Pathway. 76th General Scientific Meeting, Taiwan Surgical Association., Taipei. 

18. Yun-Ting Li, Chien-Chang Chen, Ching-Ming Chien, Yur-Ren Kuo (2017, Mar). The Effects of Regulatory Adipose-derived Stem Cells and Short-term Immunosuppressants Prolonged Allotransplant Survival in a Rodent Hind-Limb Model. 76th General Scientific Meeting, Taiwan Surgical Association., Taipei. 

19. Ching-Ming Chien, Chun-Ting Wang, Chi-Wei Hong, Yun-Ting Li,Yu-Chi Wang, Yur-Ren Kuo (2016, Sep). Hypoxia precondition cultured medium of stem cell enhance wound healing through HIF1-alpha/VEGF pathway in STZ-induced diabetic rats model. 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting (TERMIS-AP 2016), Taipei. 

20. Chi-Wei Hong, Chien-Chang Chen, Ching-Ming Chien, Chun-Ting Wang, Yun-Ting Li, Yur-Ren Kuo (2016, Mar). The Effects of Adipose-derived Stem Cells Modulated B-Cells Regulation. General Scientific Meeting, Taiwan Surgical Association., Taipei. 

21. Ching-Ming Chien, Chi-Wei Hong, Chun-Ting Wang, Yun-Ting Li, Yur-Ren Kuo (2016, Mar). The mechanisms of adipose-derived stem cells modulated dendritic cell activation.. General Scientific Meeting, Taiwan Surgical Association., Taipei.

22. Chun-Ting Wang, Ching-Ming Chien, Chi-Wei Hong, Yun-Ting Li, Yur-Ren Kuo, Ming-Yu Yang (2016, Mar). The effects of hypoxia- induced stem cells-preconditioned medium enhance diabetic wound healing in STZ-induced diabetic rats. General Scientific Meeting, Taiwan Surgical Association., Taipei. 

23. Yun-Ting Li, Yuan-Cheng Chiang, Ching-Ming Chien, Chi-Wei Hong, Chun-Ting Wang, Yur-Ren Kuo (2016, Mar). The effects of extracorporeal shock wave therapy modulate keloid fibroblast proliferation. General Scientific Meeting, Taiwan Surgical Association., Taipei. 

24. Chi-Ming Chien, Chi-Wei Hong, Chun-Ting Wang, Yun-Ting Li, Yur-Ren Kuo (2015, Dec). Novel approach to extend vascularized composite allotransplant survival duration: recipient autologous adipose-derived stem cells. New Advance in Generation Medicine and Stem Cell, Kaohsiung. 

25. Chi-Wei Hong, Chi-Ming Chien, Chun-Ting Wang, Yun-Ting Li, Yur-Ren Kuo (2015, Sep). Adipose-derived stem cells suppressed dendritic cell-based immune involved the expression of indoleamine 2,3-dioxygenase. International Conference on Stem Cells and Developmental Biology, Taipei.