NAME: Hock-Seng Nguan （阮福成）
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PERSONAL:
Current Position: Assistant Professor, Department of Applied Chemistry, National Chiayi University.
Office Address:
No. 300, Xuefu Road, East District, Chiayi City
Tel: 05-2717961
Fax:
E-mail: nguanhs@mail.ncyu.edu.tw
EDUCATION:
2013 Ph. D in Computational Chemistry, University of Malaya.
2009 M. Sc. in Applied Mathematics, University of Malaya.
2004 B. Sc. (Hon) in Physics, University of Malaya.
FIELD OF SPECIALRY:
l Computational Chemistry
l Molecular Dynamics
l Carbohydrates
EMPLOYMENT:
2026-Present Assistant Professor
Department of Applied Chemistry, National Chiayi University
2015-2026 Postdoctoral Fellow
Institute of Atomic and Molecular Sciences, Academia Sinica, Taiwan.
2013-2015 Postdoctoral Fellow
Chemistry Department, University of Malaya, Malaysia.
2009-2013 Research Assistant
Chemistry Department, University of Malaya, Malaysia.
2007-2008 Executive Officer
OYL Manufacturing, Kuala Lumpur, Malaysia.
2005-2007 Research Assistant
Mathematics Department, University of Malaya, Malaysia
RESEARCH INTEREST:
1. Quantum chemistry computation of carbohydrates dissociation in collision-induced dissociation mass spectrometry.
2. Theoretical modelling of glycoproteins and carbohydrate active enzymes (CAZyme).
3. Theoretical study of porous graphitic column (PGC) in carbohydrates separations.
4. Development of glycoinformatics software.
JOURNAL REFEREE:
Journal of molecular modeling
List of Research Publications:
JOURNAL ARTICLES:
1. Hock-Seng Nguan, Yen-Ting Lin, Chi-Kung Ni*, Unraveling Cross-Ring Dissociation Mechanisms of Hexoses in Collision-Induced Dissociation, Journal of Physical Chemistry A, (2026) 130, 17, 3430-3441
2. Hock-Seng Nguan, Hsu-Chen Hsu, Wun-Long Li, Chia Yen Liew, Chi-Kung Ni, Collision-Induced Dissociations of Linear Hexose and Disaccharides with Linear Hexose at the Reducing End, Journal of Physical Chemistry A, (2024) 128, 47, 10213-10223
3. Hock-Seng Nguan, Jien-Lian Chen, Chi-Kung Ni, Collision induced dissociation of fucose and identification of anomericity, Journal of Physical Chemistry A, (2024) 128, 19, 3812–3820
4. Chia Yen Liew, Jien-Lian Chen, Yen-Ting Lin, Hong-Sheng Luo, An-Ti Hung, Bryan John Abel Magoling, Hock-Seng Nguan, Charles Pin-Kuang Lai, Chi-Kung Ni, Chromatograms and Mass Spectra of High-Mannose and Paucimannose N-Glycans for Rapid Isomeric Identifications, Journal of Proteome Research, (2024), 23, 3, 939–955.
5. Hock-Seng Nguan, Shang-Ting Tsai, Chia Yen Liew, Sivakumar N Reddy, Shang-Cheng Hung, Chi-Kung Ni, Collision-Induced Dissociation Mechanism of Sodiated Hex–HexNAc Disaccharides, Physical Chemistry Chemical Physics, (2023) 25, 22179-22194
6. Hock-Seng Nguan, Chi-Kung Ni, Collision-Induced Dissociation of a-Isomaltose and a QUOTE
7. Liew, C. Y., Hsu, H. C., Nguan, H. S., Huang, Y. C., Zhong, Y. Q., Hung, S. C., & Ni, C. K., The Good, the Bad, and the Ugly Memories of Carbohydrate Fragments in Collision-Induced Dissociation. Journal of the American Society for Mass Spectrometry, (2022), 33(10), 1891-1903.
8. Hock-Seng Nguan, Khairul Anwar Ishak, N Idayu Zahid, Alfonso Martinez-Felipe, Rauzah Hashim, Nurul Fadhilah Kamalul Aripin, Incommensurate lamellar phase from long chain Mannosides: Investigation by X-Ray scattering and replica exchange molecular dynamics (REMD), Journal of Molecular Liquids, 356 (2022), 119027.
9. Hock-Seng Nguan, Shang-Ting Tsai, Chi-Kung Ni, Collision-Induced Dissociation of Cellobiose and Maltose, Journal of Physical Chemistry A, 126 (2022), 1486–1495.
10. Tsai, Shang-Ting; Nguan, Hock-Seng; Ni, Chi-Kung, Identification of anomericity and linkage of arabinose and ribose through collision induced dissociation, Journal of Physical Chemistry A, 125 (2021), 6109-6121.
11. Hock-Seng Nguan, S.T. Tsai, J.L. Chen, P.J. Hsu, J.L. Kuo and C.K. Ni, Collision-induced dissociation of xylose and applications on linkage and anomericity identifications, Physical Chemistry Chemical Physics, 23 (2021), 3485-3495.
12. H.T. Huynh, H.T. Phan, P.-J. Hsu, J.-L. Chen, H.S. Nguan, S.-T. Tsai, T. Roongcharoen, C.Y. Liew, C.-K. Ni, J.-L. Kuo, Collision-induced dissociation of sodiated glucose, galactose, and mannose, and the identification of anomeric configurations, Physical Chemistry Chemical Physics, 20 (2018), 19614-19624.
13. J.-L. Chen, Hock-Seng Nguan, P.-J. Hsu, S.-T. Tsai, C.Y. Liew, J.-L. Kuo, W.-P. Hu, C.-K. Ni, Collision-induced dissociation of sodiated glucose and identification of anomeric configuration, Physical Chemistry Chemical Physics, 19 (2017), 15454-15462.
14. Hashim Rauzah, Akihiko Sugimura, Hock-Seng Nguan, Matiur Rahman, and Herbert Zimmermann, Anhydrous octyl-glucoside phase transition from lamellar to isotropic induced by electric and magnetic fields, The Journal of Chemical Physics, 146 (2017), 084702.
15. Velayutham, T. S., Hock-Seng Nguan, B. K. Ng, W. C. Gan, V. Manickam Achari, N. I. Zahid, WH Abd Majid, C. Zannoni, and R. Hashim, Molecular dynamics of anhydrous glycolipid self-assembly in lamellar and hexagonal phases, Physical Chemistry Chemical Physics, 18 (2016), 15182-15190.
16. Sara Ahmadi, Vijayan ManickamAchari, Hock-Seng Nguan and Rauzah Hashim, Atomistic simulation studies of the α/β-glucoside and galactoside in anhydrous bilayers: effect of the anomeric and epimeric configurations, Journal of Molecular Modeling, 20 (2014), 2165-2176.
17. Hock-Seng Nguan, Sara Ahmadi and Rauzah Hashim, Molecular Dynamics Simulation of Lyotropic Reverse Hexagonal (HII) of Guerbet Branched-Chain β-D- Glucoside, Physical Chemistry Chemical Physics, 16 (2014), 324-334.
18. Vijayan Manickam Achari, Hock-Seng Nguan, Thorsten Heidelberg, Richard A. Bryce and Rauzah Hashim, Molecular Dynamics Study of Anhydrous Bilayers of Synthetic Glycolipids: Effects of Chain Branching and Disaccharide Headgroup, Journal of Physical Chemistry B, 116 (2012), 11626-11634.
19. Hock-Seng Nguan, Sara Ahmadi and Rauzah Hashim, DFT study of glucose based glycolipid crown ethers and their complexes with alkali metal cations Na+ and K+, Journal of Molecular Modeling,18 (2012), 5041-50.
20. Hock-Seng Nguan, T. Heidelberg, G.J.T. Tiddy and R. Hashim, Quantitative analysis of the packing of alkyl glycosides: a comparison of linear and branched alkyl chains, Liquid Crystals, 37 (2010), 1205-1213.
21. Hock-Seng Nguan and Bernardine R. Wong, Space-time trajectory approach in nuclear relativistic Coulomb excitation and its recoil correction, Jurnal Fizik Malaysia 29 (2008), 3&4.
22. Hock-Seng Nguan and Bernardine R. Wong, Relativistic Coulomb Excitation of the Giant Dipole Resonance in Nuclei using a Space-time Trajectory Approach, Jurnal Fizik Malaysia 27(2) (2006), 93-97.