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鄭建中 教授 Dr. Chien-Chung Cheng |
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現職：國立嘉義大學應用化學系教授 +886-(0)5-2766084；E-mail: cccheng@mail.ncyu.edu.tw 生物無機；核酸化學；生物有機化學
一、學歷 美國紐約州立大學石溪分校化學系博士(1989-1993) 東海大學化學系學士 (1985)
二、經歷 嘉義大學應用化學系教授（2006/08-迄今） 上海交通大學化學化工學院，訪問學者，2013/10 吉林大學超分子及材料國家重點實驗室，訪問學者，2013/08 淡江大學生命科學研究所合聘教授 (2002/08-2006/07)； 淡江大學化學系教授 (2005/02-2006/07)。 淡江大學化學系副教授 (2001/08-2005/02) 中央研究院化學所副研究員 (2000/5-2001/07) 中央研究院化學所助研究員(1996/02-2000/05)； 美國北卡羅萊那大學教堂博士後研究 (1993-1995)
三、專業領域： 生物無機；核酸化學；生物有機化學
四、連絡方式（Tel and FAX)： Tel: +886- 05-2766084; Fax: +886-05-2717901; E-mail: cccheng@mail.ncyu.edu.tw
五、研究方向： 1. DNA/RNA結構及生物功能：化學探針研究；化學感測物；含金屬之抗腫瘤試劑；DNA藥物試劑；專一辨識化學分子之DNA試管篩選 2. 化學在綠色生物材料及催化：模擬酵素催化作用；綠色化學之高溫菌催化反應；化學分子對斑馬魚的生物模擬作用；植物的活性分子分析 3. 化學分子之運送：金屬藥物的蛋白質體的作用；天然藥物修飾成運送載體；功能性脂肪球
六、選列期刊發表(Selected Publications) 校務系統研究成果 1. Cheng, C.-C.; Lu, Y.-L.; Lo, C.-J. “DNA cleavage of Water-soluble Ruthenium(III) Complexes Containing Pyridiyl-Schiff Based in the Presence of H2O2,” Bull. Inst. Chem. Acad. Sinica 1997, 44, 61-69.
2. Cheng, C.-C. and Pai, C.-H. “Specific Displacement of Glutathione from the Pt(II)-Glutathione Adduct from the Pt(II)-Glutathione Adduct,” J. Inorg. Biochem. 1998, 71, 109-113.
3. Cheng, C.-C.; Jian, Y.-H.; Lo, C.-J. and Cheng, J.-W. “Design and Characterization of a Short HMG-I / DAT1 Peptide that Binds Specifically to the Minor Groove of DNA,” J. Chin. Chem. Soc. 1998, 45, 619-624.
4. Cheng, C.-C. and Lu, Y.-L. “Novel Water-Soluble 4,4’-Disubstituted Ruthenium(III)-Salen Complexes in DNA Stranded Scission,” J. Chin. Chem. Soc. 1998, 45, 611-617.
5. Cheng, C.-C. and Lu, Y.-L. “Cleavage of Pt-S bond of Platinum-thiolated Complexes Mediated by Cu(II) and Zn(II) ain Phosphate buffer,” Chem. Commun. 1998, 253. 5.504
6. Carter, P. J.; Cheng, C.-C. and Thorp, H. H. “Oxidation of DNA and RNA by oxoruthenium(IV) Metallointercalators: Visualizing the Recognition Properties of Dipyridophenazine by High-Resolution Electrophoresis,” J. Am. Chem. Soc. 1998, 120, 632-642.
7. Cheng, C.-C.; Kuo, Y.-N.; Chuang, K.-S.; Luo, C. F. and Wang, W. C. “CoII (HAPP) (TFA)2 Complex: a DNA Bulge-Specific Probe,” Angew. Chem. Intl. Ed. Engl., 1999, 38, 1255-1257.
8. Cheng, C.-C. and Liu, M.-C. “Novel Ca2+-Specific Receptors Derived from 3-Formyl-2-Hydroxybenzoic Acid,” Tetrahedron Lett., 2000, 41, 10047-10053.
9. Cheng, C.-C.; Lee, W.-L.; Su, C.-K.; Liu, C.-L. “Determination of DNA Covalent Bond Formation of Ru(terpy)(tmephen)Cl+: A Potential Metal-Based Anticancer Drug,” J. Chin. Chem. Soc. 2000, 47, 213-220.
10. Yang, C.-H; Chou, P.-J.; Zhen, Chang, J.-C.; Cheng, C.-C. “Preferential binding to DNA sequences of peptides related to a novel XPRK motif,” Bioorganic and Medicinal Chemistry 2003, 11, 3279-3288.
11. Ong, C. W.; Chang, Y. A.; Wu, J.-Y. and Cheng, C.-C. “Novel design of a pentacyclic scaffold as structural mimic of saframycin A,” Tetrahedron 2003, 59, 8245-8249.
12. Cheng, C.-C.; Hung, S.-M.; Yeh, C.-Y.; Chang, C.-S. and Wang, W. J. “Novel DNA binding agents: hydrazone-based helical trinuclear Ag complexes,” J. Chin. Chem. Soc. 2003, 50, 189-192.
13. Cheng, C.-C.; Huang-Fu, W.-C.; Hung, K.-C.; Chen, P.-J.; Wang, W. J.; Chen, Y.-J. “Mechanistic Aspect of Co(HAPP)(TFA)2 in DNA Bulge-Specific Recognition,” Nucleic Acids Research 2003, 31, 2227-2233.
14. Chen, Y.-J.; Chen, P.-J.; Wang, H.-T.; Cheng, C.-C. ”Specific Recognition of DNA Bulge Structure by Matrix-assisted Laser Desorption/Ionization Time-of-flight Mass Spectrometry,” Rapid Comm. Mass Spec. 2004, 18, 609-616.
15. Chang, J.- C.; Yang., C.- H.; Chou, P.- Y.; Yang, W.- H.; Chou, I.- C. Lu, C- T.; Lin, P.- H.; Hou, P. C.- W.; Jeng, K.- C. G.; Cheng, C.- C. and L. Sheh “DNA Sequence-specific Recognition of Peptides Incorporating the HPRK and Polyamide Motifs,” Bioorganic and Medicinal Chemistry 2004, 12(1) , 53-61
16. Lin, C.-C.; Hung, S.-M.; Lee, K.-C. and Cheng, C.-C. “pH Dependent Thermal Stabilization of DNA by Glcb(1→3)GlcNAcb1→STol,” J. Chin. Chem. Soc. 2004, 51(3), 655-658.
17. Cheng, C.-C.; Huang, Y.-C. and Liu., M.-C. “DNA Hydrolysis Catalyzed by Tris(diisopropyl-1,4,7- triazacyclononanes)ethane Metal Complexes” J. Chin. Chem. Soc. 2004, 51(5B), 1201-1208.
18. Chen, C.-T.; Lin, J.-S.; Kuo, J.-H.;Weng, S.-S.;Cuo, T.-S.; Lin, Y.-W.; Cheng, C.-C.; Huang, Y.-C.; Yu, J.-K., Chou, P.-T. “Site-Selective DNA Photocleavage Involving Unusual Photoinitiated Tautomerization of Chiral Tridentate Vanadyl(V) Complexes Derived from N-Salicylidene <!--[if !vml]--><!--[endif]-->-Amino Acids,” Org. Lett., 2004, 6(24), 4471 -4474.
19. Cheng, C.-C.; Hung, K. C.; Huang-Fu, W. C. “Differentiate RNA single-stranded region of the branched structures and hairpin loops by an octahedral cobalt(II) complex” J. Chin. Chem. Soc. 2005, 52, 1291-1297.
20. Hui-Huang Hsu,* Chao-Hsun Yang, Cheng-Wei Hsieh, and Chien-Chung Cheng, “Networked Information Integration for Protein Identification,” Journal of Information Technology, 2008, 9(1), 101-109.
21. Wang YH, Wen CC, Yang ZS, Cheng CC, Tsai, JN, Ku CC, Wu HJ and Chen YH* “Development of a whole-organism model to screen new compounds for sun protection.” Marine Biotechnology, 2008, Online Original Article
22. Ming-Yi Ho, Yu-Tse Shieh , Chung-Lin Liao , Yau-Hung Chen , Chien-Chung Cheng, “Functional dihydro-1H-imidazole derivatives for MALDI signal enhancement of a lysine-specific chemical modification” J. Chin. Chem. Soc. 2009, 56, 987-994.
23. Yun-Hsin Wang, Chien-Chung Cheng, Wen-Jie Lee, Min-Lun Chiou, Chiung-Wen Pai, Chi-Chung Wen, Wei-Li Chen, and Yau-Hung Chen. “A novel phenotype-based approach for systematically screening antiproliferation metallodrugs”, Chemico-Biological Interactions, 2009, 182, 84–91.
24. Ming-Yi Ho, Min-Lun Chiou, Ruei-Chi Chang, Yau-Hung Chen, Chien-Chung Cheng. “Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli” J. Inorg. Biochem. 2010, 104, 614-617.
25. Hsi-Chu Peng, Yun-Hsin Wang, Chi-Chung Wen, Wei-Hua Wang, Chien-Chung Cheng, Yau-Hung Chen “Nephrotoxicity assessments of acetaminophen during zebrafish embryogenesis” Comp. Biochem. Physiol. C. 2010, 151, 480-486.
26. Yau-Hung Chen,* Chien-Hui Chiou, Wei-Li Chen, Yu-Ru Jhou, Ya-Ting Lee, Chien-Chung Cheng,* “Rhodamine-Ethylenediol, A Novel Vital Fluorescent Probe for Labelling Alkaline Phosphatase-Rich Organelles” J. Chin. Chem. Soc. 2010, 57, 1257-1261.
27. Yau-Hung Chen*, Min-Chuan Chiou, Yun-Feng Liao, Jen-Ning Tsai, Chi-Chung Wen, Yun-Hsin Wang, and Chien-Chung Cheng* “Resveratrol Treatment Attenuates the Wound-induced Inflammation in Zebrafish Larvae through the Suppression of Myeloperoxidase Expression” J. Food. Drug Anal. 2011, 19, 167-173.
28. Ming-Yi Ho, Min-Lun Chiou, Wan-Shan Du, Fang Ying Chang, Yau-Hung Chen, Yu-Jong Weng, Chien-Chung Cheng,* “Inductive properties of polypyridyl ruthenium complexes significantly regulate various protein distributions in Escherichia coli” J. Inorg. Biochem. 2011,105, 902-910.
29. Chen YH, Tsai IT, Wen CC, Wang YH, Cheng CC, Hu SC, Chen YH*, “Fin-reduction is a novel and unexpected teratogenic effect of amikacin-treated zebrafish embryos” Toxicology Mechanisms and Methods 2012; 22(2): 151–158.
30. Tsai IT, Yang ZS, Lin ZY, Wen CC, Cheng CC, Chen YH, “Flavone is efficient to protect zebrafish fins from UV-induced damage”, Drug and Chemical Toxicology, 2012, 35(3), 341-6.
31. Yeh CH, Liao YF, Chang CY, Tsai JN, Wang YH, Cheng CC, Wen CC, Chen YH* “Caffeine treatment disturbs the angiogenesis of zebrafish larvae.” Drug Chem. Toxicol. 2012, 35, 361-365.
32. Yu-Ru Jhou, Chien-Hui Chiou, Lin-Kia Ni, Li-Chou Chen, Yau-Hung Chen, and Chien-Chung Cheng ”Cellular uptake of a polypyridyl ruthenium complex revealed using a fluorescent rhodamine-modified ruthenium complex”, J. Chin. Chem. Soc. 2012, 59, 1053-1057.
33. Der-Lii M. Tzou,* Lin-Kai Ni, Mei-Man Chen, Min-Chuan Chiou, Li-Chou Chen, Shan-Te Hsu, Kuo-Lung Ku, and Chien-Chung Cheng,* “Solid-state 13C NMR analysis of Phalaenopsis tissues during the growth period and spiking induction”, J. Chin. Chem. Soc. 2013, 60, 1107-1112. (Cover) (2014 CCS Award)
34. Li-Chou Chen, Shih-Shan Lin, Cun-Zhao Li, Hsiu-Fu Hsu,* Yu-Jong Weng, Chien-Chung Cheng,* “Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release”, J. Chin. Chem. Soc. 2013, 60, 1099-1102.
35. Cheng CC*, Chou CY, Chang YC, Wang HW, Wen CC, Chen YH*, “Protective role of comfrey leave extracts on UV-induced zebrafish fin damages” Journal of Toxicologic Pathology, 2014, 27, 115-121.
36. Shan-Te Hsu, Wan-Shan Du, Hsing-Chin Liu, Le-Chou Cheng, Chien-Chung Cheng* “Protein Redistribution and Stalk Localization Following Temperature Variation in the Growth and Spiking Period of Phalaenopsis”, J. Chin. Chem. Soc. 2014, 61(11), 1231-1236
37. Yue-Jyun Chen, Chi-Yuan Chou, Chi-Chung Wen, Chen-Yu Fan, Chien-Chung Cheng *, Yau-Hung Chen “UV-protective activities of pineapple leaves extract in zebrafish embryos” 2015, submitted
38. Chen, Chien-Han; Hu, Tsung-Hao; Huang, Tzu-Chiao; Chen, Ying-Lan; Chen, Yet-Ran; Cheng, Chien-Chung; Chen, Chao-Tsen "A Site‐Specific Telomeric G‐Quadruplex Alkylating Agent", 2015 submitted
39. Deyue Yan, Lin-Kai Ni, Ho-Lun Chen, Li-Chou Chen, Yau-Hung Chen, Chien-Chung Cheng "Amphiphilic Nanoparticles of Resveratrol-Norcantharidin to Enhance the Toxicity in Zebrafish Embryo", 2016 submitted
專書 三大科技革命與時空宇宙：生化科技革命 2002 ，淡江大學出版社。
專利 1. A specific DNA probe: CoII(HAPP)(TFA)2 complexes (USA Patent No. 6,348,588B1, 2002) 2. Nucleic acid bulge-detecting agent (US Patent No. 6,770,760, August 3, 2004) 3. 專利：「核酸突起結構的偵測劑」，台灣專利案(證號：I222452，2003)
七、 研討會論文 國際學術邀請演講（2001-迄今） 1. 第十屆國際生物無機會議，義大利的佛羅倫斯，至31日。 “Mechanistic studies of a DNA/RNA Bulge-specific detecting agent: Co(HAPP)(TFA)22+”， 2. 第8屆國際應用生物無機會議，香港的香港大學，至5日 “Differentiate RNA Branched Structures by Selective Cleavage with an Octahedral Co (II) Complex” 3. 第3屆亞洲生物無機會議，南京大學，至11月4日。 “Study of the Structure-Reactivity Relationship of Polypyridyl Ruthenium Complexes by Proteomics” 4. 2nd Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Oct 23-26, 2009 Title: “Outer membrane protein OmpF involved in the transportation of polypyridyl ruthenium complexes into Escherichia coli”. 5. Taipei-Shanghai Symposium of Materials Chemistry台北-上海材料化學學術研討會Academia Sinica, Taipei, Taiwan, Nov 27- Dec 2, 2009. “Alkaline Phosphatase-Specific Recognition by a Fluorescent Probe of Rhodamine-Ethylenediol Disclosed by Zebrafish” 6. Taipei-Shanghai Symposium of Materials Chemistry（滬台材料化學學術研討會）Shanghai, July 21-24, 2011 “Specific Chiral Recognition of Monosaccharides by DNA Biosensors” 7. The Supramolecular Symposium: Dynamics and Adaption, Hangzhou, China, November 4-6th, 2012. “Formation of Self-Assembling Helical Conformation by Aliphatic Resveratrol Derivatives” 8. 2013 Taipei-Shanghai Symposium of Materials Chemistry（滬台材料化學學術研討會）, Kaohsiung, November, 8-12, 2013. ” Dynamic structural transformation of resveratrol-modified stearate liposomes to a metastable helical supra-structure for drug release” 9. 2014 Korea-Taiwan Bilateral Symposium, Sogang University, Korea, Jan. 12-16, 2014. “Self-Assembly of 10. The 8th Taiwan-Japan Bilateral Symposium on Architecture of Functional Organic Molecules, Kyushu University, Japan, November 27-29, 2014. “Self-Assembly of 4-Vinylphenol Based Amphiphiles for Drug Delivery and Release”
短期參訪演講 2014 杭州浙江大學高分子所邀請訪問。時間：2014年05月26至29日；地點：浙江大學玉泉校區， 講題：Investigation of Potential Antitumor Ruthenium Complexes by Proteomics and Development of Resveratrol-Modified Liposomes for Drug Delivery
國內會議邀請演講（選列） 2007台灣生物無機年會 （嘉義大學應化系主辦） 2008無機錯鹽研討會（東吳大學化學系主辦） 2010台灣化學年會（台灣大學化學系主辦） ”Ru-protein interactions of antitumor reagents of polypyridiyl Ru(II) complexes in E. coli revealed by metalloproteomics” 2011台灣化學年會（由清華大學化學系主辦）”Trans Influence of Polypyridyl Ru(II) Complexes Significantly Influenced the Ru-Protein Interactions in Escherichia coli Revealed by Metalloproteomics” 2014 Southern Taiwan Frontier Conference in Applied Chemistry, Keynote Lecture, National Ping-Tung University, Nov.15-16, 2014 “Multi-Functional Liposomes Assembled by Natural-Product-Based Materials for Drug Delivery
國際會議壁報論文發表 (選列 2002 -迄今) 1. 第三十五屆國際配位化學會議 (35th International Conference of Coordination Chemistry) 地點：德國的海德堡(Heidelberg，Germany)；時間：日至26日 題目：Novel DNA binding agents: the self-assembling trinuclear Ag complexes 2. 第十一屆國際生物無機會議 (11th International Conference of Biological Inorganic Chemistry) 地點：澳洲的凱恩斯；時間：日至23日，會期共五天。 題目：DNA hydrolysis by Tris-triazacyclononanes Metal Complexes 3. 第14屆國際均勻相催化化學會議 (14th International Symposium on Homogeneous Catalysis) 地點：德國的慕尼黑；時間：至9日，會期共五天。 題目：Catalytic Epoxidation by Spatial Orientation of Tris(1,4,7-triazacyclononanemethyl)- ethane Metal Complexes 4. 第十三屆國際有機金屬化學導引有機合成會議（OMCOS-13）， 地點：瑞士的日內瓦，時間：至21日， 題目：Hydrophobic Cavity of Macrocyclic Metal Complexes in Catalytic Epoxidation 5. 第十二屆國際高分子暨有機化學會議12th International Conference on Polymers and Organic Chemistry。地點：日本岡崎(Okazaki)，時間：至7日 6. 第十三屆國際生物無機會議 (13th International Conference of Biological Inorganic Chemistry)，地點：奧地利的維也納，時間：2007年7月15日至20日 題目：Structure-Reactivity Relationship of Polypyridyl Ru Complexes in Proteomics and Zerbrafish 7. 第十四屆國際進階選擇性催化會前會議(ICC-14 Pre-Symposium) 地點：日本的京都，時間：2008 年7 月8 至12日， 題目：Tris(1,4,7-triazacyclononanemethyl)ethane-based Multi-nuclear Metal Complexes in Catalytic Epoxidation and DNA Hydrolysis 8. 第四屆亞洲生物無機會議 (4th Asia Biological Inorganic Chemistry)。 地點：韓國濟州島，時間：2008年11月9日至13日 題目一：Stress-Regulated Transportation of E. Coli. Induced by Polypyridyl Ruthenium Complexes by Metalloprotomic 題目二：Synthesis of Fluorescent Polypyridyl Ruthenium Complexes for Metallopharmaceuticals 題目三：Catalytic Epoxidation and DNA Hydrolysis by Tris(1,4,7-triazacyclononanemethyl)ethane-based Multi-nuclear Metal Complexes 題目四：Metal-dependent hydrolysis of phosphoester using hyperthermophilic proteins 9. 第十四屆國際生物無機會議 (14th International Conference of Biological Inorganic Chemistry)，地點：日本的名古屋，時間：2009年7月25日至30日 題目一：Stress-Regulated Transportation by Polypyridyl Ruthenium Complexes in E. Coli. Identified by Metalloprotomics 題目二：Metalloproteomics of Polypyridyl Ruthenium Complexes Explored by LC-Nanospray-MS. 10.第三十九屆國際配位化學會議 (39th International Conference of Coordination Chemistry) 地點：澳洲的阿得雷德(Adelaide，Australia)；時間：2010 年7月25日至30日 題目：Modified Bipyridine Ligand of Ruthenium Complexes Related to the Anti-proliferations in Zebrafish 11. 第十五屆國際生物無機會議 (15th International Conference of Biological Inorganic Chemistry)，地點：加拿大溫哥華 (Vancouver, Canada)，時間：2011年8月7日至12日 題目：Trans-influence of polypyridyl ruthenium complexes related to various protein distributions in Escherichia coli by metalloproteomics 12. 15th International Symposium on Novel Aromatic Compounds (ISNA-15), Taipei, July 28-August 02, 2013. “Resveratrol-modified Stearate Liposomes Induced Spontaneous Drug Release by Dynamic Structural Transformation”
國內之科普演講 2010 擔任「科學到民間-真理大學麻豆校區場次」義務講師；時間：12月30日；地點：真理大學台南麻豆校區；( 慶祝科學月刊四十週年科學到民間科普系列講座)；講題：生活分子與分子生活； 2012 擔任「科學到民間」系列講師，時間：06月17日；地點：台北市立圖書館內湖分館；講題：生活分子與分子生活 2013「高中優質化策略聯盟」邀請之科普講座。時間：04月01日；地點：嘉義縣竹崎高中，講題：生活分子與分子生活
八、獲獎榮譽 1999 中國化學學會傑出青年化學獎章 1999 國科會績優新進研究人員 2001 國科會績優新進研究人員 2004 淡江大學92學年度優良導師獎 2012 嘉義大學100學年度教學績優/教學肯定獎 2013 嘉義大學101年度傑出通識教育教師獎 2014 中國化學會誌論文獎
九、學術專業服務經歷 2003，2004，2005，2006台灣生物無機會議，籌備委員 2000，2001，2007台灣生物無機會議，主辦人 2000-2013 台灣生物無機小組，委員 2006 國科會自然處化學學門，諮詢委員 2006 95年中國化學年會，學術演講召集人 2007-2010 Asian Biological Inorganic Chemistry Organization committee member. 2010，第五屆亞洲生物無機會議，籌備委員 2011，2012，台灣生物無機協會，理事 2012-2014，台灣化學學會之嘉義分會理事 2013，台灣生物無機協會，監事 2015 台灣化學學會之嘉義分會理事
十、產學及其他相關服務 2000-2001，百恩諾生物科技公司，顧問 2010-2014，百菲生技股份有限公司，顧問 2011，嘉大蘭花研發團隊成員之一。開發保養產品「嘉蘭之心潤膚水」 2012，台南市101學年度教師甄試複試評審委員 2012，嘉大應化系之「嘉大白面膜」開發小組 2013，2014，2015 擔任「國家圖書館」之選書委員（知識性圖書組） 2014-present，So Organic Biotech Enterprise (SOBE) LTD.，顧問 | |
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十一、教授課目 生物無機；核酸化學；生物有機化學 | |