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Che Wei Wu, Ph. D.


Che Wei Wu Assistant Professor
Education：Ph. D., Ph.D.in Agriculture Sciences University of Tsukuba  
Research Area：Food science, functional food, nutrition, biotechnology, biochemistry, cell biology, orthopedics, stem cells and regenerative medicine, tissue engineering, exosomes, mitochondria and aging medicine
Phone： 
E-mail: tetsuigo@mail.ncyu.edu.tw


期刊論文：
  1. Chewei Wu; Yaohui Huang; Peilin Shao; Linghua Chang; Chengchang Lu; Chunghwan Chen; Yinchih Fu; Meiling Ho; Jeken Chang; Shuncheng Wu (2026, May). Mitochondrial transfer from adipose-derived stem cells improves the chondrogenic phenotype in senescent chondrocytes by ameliorating mitochondrial dysfunction. European Cells & Materials , 57(2026), 82–101. (SCIE). 本人為第一作者.
  2. Ya-Shuan Chou; Shu-Chun Chuang; Che Wei Wu; Yun-Ya Tsao; Chung-Hwan Chen; Mei-Ling Ho; Je-Ken Chang (2026, May). G Protein-Coupled estrogen receptor negatively regulates cell rigidity and osteogenic differentiation in bone marrow-derived mesenchymal stem cells. Biochemical Pharmacology, 251 (2026) 118079. (SCIE).
  3. Shun-Cheng Wu, Ling-Hua Chang, Che-Wei Wu, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho (2026, Apr). Extracellular vesicles secreted by adipose- derived stem cells alleviate dedifferentiation and senescence in monolayer- expanded chondrocytes by suppressing interleukin-1β-induced MAPK signaling. Cell Transplantation. NSTC 114-2314-B-264-002.
  4. Che-Wei Wu; Yao-Hui Huang; Pei-Lin Shao; Ling-Hua Chang; Cheng-Chang Lu; Chung-Hwan Chen; Yin-Chih Fu; Mei-Ling Ho; Je-Ken Chang; Shun-Cheng Wu (2025, Aug). Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles Enhance Chondrocyte Function by Reducing Oxidative Stress in Chondrocytes . International Journal of Molecular Sciences . (SCI, 72/319, BIOCHEMISTRY & MOLECULAR BIOLOGY). NSTC 114-2314-B-264-002. 本人為第一作者.
  5. Ling-Hua Chang,Shu-Chun Chuang,Shun-Cheng Wu,Yin-Chih Fu,Jhen-Wei Chen,Che-Wei Wu,Yi-Shan Lin,Cyong-Yue Liu,Yu-Hsuan Chung,Je-Ken Chang,Chung-Hwan Chen, Mei-Ling Ho (2025, Aug). Comparisons of miRNA profiles of exosomes derived from human iPSCs, ADSCs, and BMSCs and effects on chondrocyte function. Bone & Joint Research , 14(8), 696-671. (SCI, 6/139, ORTHOPEDICS).
  6. Chih-Yun Lee, Swathi Nedunchezian, Sung-Yen Lin, Yu-Feng Su, Che-Wei Wu, Shun-Cheng Wu, Chung-Hwan Chen, Chih-Kuang Wang (2023, Nov). Bilayer osteochondral graft in rabbit xenogeneic transplantation model comprising sintered 3D-printed bioceramic and human adipose-derived stem cells laden biohydrogel. Journal of Biological Engineering . (SCI, 7/85, BIOCHEMICAL RESEARCH METHODS).
  7. Han Lee, Jiunn-Der Liao, Tak-Wah Wong, Che-Wei Wu, Bo-Yao Huang, Shun- Cheng Wu, Pei-Lin Shao, Yu-Han Wei, Ming-Hsien Cheng (2023, Nov). Detection of micro-plasma-induced exosomes secretion in a fibroblast-melanoma co-culture model. . (SCI, 11/106, CHEMISTRY, ANALYTICAL).
  8. Ling-Hua Chang, Shun-Cheng Wu, Chung-Hwan Chen, Jhen-Wei Chen, Wan- Chun Huang, Che-Wei Wu, Yi-Shan Lin, Yu-Ju Chen, Je-Ken Chang, Mei-Ling Ho (2023, Aug). Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression . International Journal of Molecular Sciences . (SCI, 25/174, BIOCHEMISTRY & MOLECULAR BIOLOGY).
  9. Mei-Ling Ho; Chin-Jung Hsu; Che-Wei Wu; Ling-Hua Chang; Jhen-Wei Chen; Chung-Hwan Chen; Kui-Chou Huang; Je-Ken Chang; Shun-Cheng Wu; Pei-Lin Shao (2022, Jul). Enhancement of Osteoblast Function through Extracellular Vesicles Derived from Adipose-Derived Stem Cells. Biomedicines, Biomedicines 2022, 10(7), 1752. (SCI, 54/136, MEDICINE, RESEARCH & EXPERIMENTAL).
  10. Swathi Nedunchezian; Che-Wei Wu; Shung-Cheng Wu; Chung-Hwan Chen; Je- Ken Chang; Chih-Kuang Wang (2022, May). Characteristic and Chondrogenic Differentiation Analysis of Hybrid Hydrogels Comprised of Hyaluronic Acid Methacryloyl (HAMA), Gelatin Methacryloyl (GelMA), and the Acrylate- Functionalized Nano-Silica Crosslinker . Polymers, Polymers 2022, 14(10), 2003. (SCI, 16/86, POLYMER SCIENCE).
  11. Shun-Cheng Wu, Chih-Hsiang Chang, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Yi-Shan Lin, Je-Ken Chang, Mei-Ling Ho. (2021, May). Simvastatin Enhances the Chondrogenesis But Not the Osteogenesis of Adipose-Derived Stem Cells in a Hyaluronan Microenvironment. . Biomedicines, 9(5), 559. (SCI, 62/139, MEDICINE, RESEARCH & EXPERIMENTAL).
  12. Swathi Nedunchezian, Parikshit Banerjee, Chih-Yun Lee, Su-Shin Lee, Che-Wei Lin, Che-Wei Wu, Shun-Cheng Wu, Je-Ken Chang, Chih Kuang Wang. (2021, May). Generating adipose stem cell-laden hyaluronic acid-based scaffolds using 3D bioprinting via the double crosslinked strategy for chondrogenesis.. Materials Science and Engineering: C, 124:112072. (SCI, 57/214, MATERIALS SCIENCE, MULTIDISCIPLINARY).
  13. Che Wei Wu, Yoshihiro Nakamoto, Takumaru Hisatome, Shigeki Yoshida, Hitoshi Miyazaki. (2020, Jul). Resveratrol and its dimers ε-viniferin and δ- viniferin in red wine protect vascular endothelial cells by a similar mechanism with different potency and efficacy.. The Kaohsiung Journal of Medical Sciences, 36(7):535-542. . (SCI, 93/140, MEDICINE, RESEARCH & EXPERIMENTAL). 本人為第一作者.
  14. Ming-Wei Hung, Che-Wei Wu, Daichi Kokubu, Shigeki Yoshida, Hitoshi Miyazaki. (2019, Jan). ε-Viniferin is More Effective than Resveratrol in Promoting Favorable Adipocyte Differentiation with Enhanced Adiponectin Expression and Decreased Lipid Accumulation.. Food Science and Technology Research, 25(6): 817-826. (SCI, 125/139, FOOD SCIENCE & TECHNOLOGY).
  15. Shun-Cheng Wu, Pei-Yi Huang, Chung-Hwan Chen, Benjamin Teong, Jhen-Wei Chen, Che-Wei Wu, Je-Ken Chang, Mei-Ling Ho. (2018, Sep). Hyaluronan microenvironment enhances cartilage regeneration of human adipose-derived stem cells in a chondral defect model.. International Journal of Biological Macromolecules, 119:726-740. (SCI, 52/299,BIOCHEMISTRY & MOLECULAR BIOLOGY).

會議論文：
  1. Che-Wei Wu, Yao-Hui Huang, Pei-Lin Shao, Ling-Hua Chang, Cheng-Chang Lu, Chung-Hwan Chen, Yin-Chih Fu, Mei-Ling Ho, Je-Ken Chang and Shun-Cheng Wu Wharton’s Jelly-Derived Extracellular Vesicles Promote Chondrocyte Proliferation and Chondrogenesis, and Mitigate Oxidative Stress ORS 2026 Annual Meeting March 27-31 2026, Charlotte, North Carolina,.
  2. Che-Wei Wu, Yin-Chih Fu, Pei-Lin Shao, Ling-Hua Chang, Ya-Shuan Chou, Yun-Ya Tsao, Shun-Cheng Wu. Effect of Wharton's jelly mesenchymal stem cells secrete extracellular vesicles on cell proliferation, survival and oxidative stress in chondrocytes ORS 2025 Annual Meeting February 7 – 11, 2025 Phoenix Convention Center Phoenix, AZ
  3. 吳冠諺#, 王天鍇#, 傅尹志, 邵佩琳, 張玲華, 鄒亞璇, 伍哲緯*, 吳順成* 測試臍帶間質幹細胞分泌之細胞外囊泡對於軟骨細胞存活及增殖之影響 The effect of Wharton's jelly mesenchymal stem cells secreted extracellular vesicles on survival and proliferation in chondrocytes. 2025 Taiwan Regenerative Medicine Summit; 2025, April 10th. Kaohsiung
  4. 邱彥瑄#, 邱彥瑜#, 傅尹志, 邵佩琳, 張玲華, 鄒亞璇, 伍哲緯*, 吳順成* 臍帶間質幹細胞分泌之細胞外囊泡可減少軟骨細胞之氧化壓力 Wharton's jelly mesenchymal stem cells secreted extracellular vesicles reduce oxidative stress in chondrocytes. 2025 Taiwan Regenerative Medicine Summit; 2025, April 10th. Kaohsiung
  5. #Pei-Lin Shao, #Che-Wei Wu, Yin-Chih Fu, Ling-Hua Chang, Ya-Shuan Chou, Yun-Ya Tsao, *Shun-Cheng Wu EXTRACELLULAR VESICLES SECRETED BY WHARTON'S JELLY MESENCHYMAL STEM CELLS ENHANCE PROLIFERATION AND ALLEVIATE OXIDATIVE STRESS IN CHONDROCYTES ICORS CONGRESS 2025 Adelaide, South Australia 8 – 11 October 2025.
  6. 伍哲緯, 傅尹志, 邵佩琳, 張玲華, 陳崇桓, 盧政昌, 何美泠, 張瑞根, 吳順成*  The Effect of Wharton's Jelly Mesenchymal Stem Cells Secreted Extracellular Vesicles (WJMSC-Evs) on Oxidative Stress and Oxidative Metabolism In Chondrocytes 華通氏膠間質幹細胞分泌之細胞外囊泡對於軟骨細胞之氧化壓力及氧化代謝之影響 ; Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會113年度第86次聯合學術研討會、October 26-27, 2024
  7. 伍哲緯, 黃耀輝, 張玲華, 邵佩琳, 陳崇桓, 張瑞根, 何美泠, 盧政昌, 吳順成*  ADSCs-Derived Mitochondrial Transfer Improves Chondrogenic Phenotype by Ameliorating Senescence and Mitochondria Dysfunction in Chondrocytes 脂肪幹細胞來源的粒線體轉移可改善軟骨細胞之軟骨表型透過改善細胞衰老和粒線體功能障礙 ; Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會113年度第86次聯合學術研討會、October 26-27, 2024
  8. 伍哲緯,黃耀輝, 張玲華, 陳崇桓, 張瑞根, 何美泠, 盧政昌, 邵佩琳, 吳順成* The study of mitochondrial transfer of adipose derived stem cells into chondrocytes for articular cartilage tissue engineering; 2024基礎到臨床：由細胞到機器手臂，全方位的膝關節炎治療對策研討會 2024 Bench to Clinic：From Cells to Robotics for Knee OA Treatment、2024.06.29 亞東紀念醫院 14F 國際會議廳
  9. Pei-Lin Shao; Che Wei Wu; Cheng-Chang Lu; Linghua Chang; Jhen-Wei Chen; Chung-Hwan Chen; Je-Ken Chang; Mei-Ling Ho; He-Guei Chen; Shun-Cheng Wu * Adipose-derived Stem Cells Co-culture With Chondrocytes Secrete Extracellular Vesicles Maintain Chondrogenic Phenotype Of Serially Passaged Chondrocytes; Orthopaedic Research Society 2024 Annual Meeting; USA, Long Beach, California, February 2-6, 2024.
  10. 邵佩琳, 伍哲緯, 張玲華, 陳振偉, 盧政昌, 陳崇桓, 張瑞根, 何美泠, 陳禾桂, 吳順成* Extracellular Vesicles Derived from Adipose-Derived Stem Cells Co-Culture with Chondrocytes Maintain Chondrogenic Phenotype of Monolayer-Expanded Chondrocytes 細胞外囊泡取自脂肪幹細胞與軟骨細胞共同培養可維持單層培養軟骨細胞之細胞表型; Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會113年度第85次聯合學術研討會、April 20, 2024
  11. 邵佩琳, 伍哲緯, 黃耀輝, 張玲華, 陳振偉, 鄒亞璇, 何美泠, 吳順成* Mitochondrial Transfer of Adipose-Derived Stem Cells Recovers Mitochondrial and Cartilage Functions of Senescent Chondrocytes ADSC 粒線體移植能恢復衰老軟骨細胞的粒線體和軟骨功能; Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會113年度第85次聯合學術研討會、April 20, 2024
  12. Shun-Cheng Wu, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho*; Enhancement of senescent chondrocyte function by extracellular vesicles released from human adipose-derived stem cells; Orthopaedic Research Society 2023 Annual Meeting; USA, Hilton Anatole, Dallas, Texas, February 10-14, 2023.
  13. Che-Wei Wu, Yao-Hui Huang, Pei-Ling Shao, Ling-Hua Chang, Jhen-Wei Chen, Mei-Ling Ho, Shun-Cheng Wu*; Mitochondrial transfer suppresses senescence induced mitochondrial dysfunction and oxidative stress in chondrocytes; Orthopaedic Research Society 2023 Annual Meeting; USA, Hilton Anatole, Dallas, Texas, February 10-14, 2023.
  14. Che-Wei Wu, Mei-Ling Ho, Jhen-Wei Chen, Shun-Cheng Wu, Pei-Lin Shao Enhancement of osteogenesis of osteoblasts in vitro by extracellular vesicles derived from adipose derived stem cells 2023 亞太胞外體學會大會; 國家生技研究園區(臺北市南港區研究院路一段130巷99號C棟); March 31-April 2, 2023. 
  15. Shun-Cheng Wu; Ling-hua Chang; Che-Wei Wu; Chung-Hwan Chen; Je-Ken Chang; Mei-Ling Ho; Extracellular Vesicles Released From Human Adipose-derived Stem Cells Reduce Senescence And Dedifferentiation Of Articular Chondrocyte; Orthopaedic Research Society 2022 Annual Meeting; USA, Florida, February 4-8, 2022. 
  16. 伍哲緯, 何美泠, 張瑞根, 陳崇桓, 黃揆洲, 許晉榮,吳順成*, 邵佩琳* Characterization of Adipose Derived Stem Cells-Derived Extracellular Vesicles and Its Effects on Osteoblastic Functions 脂肪幹細胞分泌之細胞外囊泡之鑑定及其對於成骨細胞之功能 Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科學會110 年度第80次聯合學術研討會、December 30-31, 2021 
  17. Shun-Cheng Wu, Ling-Hua Chang, Che-Wei Wu, Jhen-Wei Chen, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho*  Extracellular vesicles released from human adipose-derived stem cells enhance articular chondrocyte function. Orthopaedic Research Society 2021 Annual Meeting; All access, February 12-16, 2021.
  18. 吳順成, 陳振偉, 伍哲緯, 張玲華, 陳崇桓, 張瑞根*, 何美泠* Extracellular vesicles released from human adipose-derived stem cells enhance articular chondrocyte function. 人類脂肪幹細胞釋放的細胞外囊泡可增強關節軟骨細胞功能 Annual Meeting of Taiwan Orthopaedic Association 中華民國骨科醫學會109年度第78次聯合學術研討會 October 24-25, 2020.
  19. Shun-Cheng Wu, Jhen-Wei Chen, Che-Wei Wu, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho Adipose-derived stem cells enhance chondrogenesis and cartilaginous matrix synthesis of articular chondrocytes is mediated by extracellular vesicles. Orthopaedic Research Society 2020 Annual Meeting; USA, Phoenix, February 8-11, 2020.
  20. Shun-Cheng Wu, Jhen-Wei Chen, Che-Wei Wu, Chung-Hwan Chen, Je-Ken Chang, Mei-Ling Ho. Adipose-derived stem cells enhance chondrogenesis and cartilaginous matrix synthesis of articular chondrocytes is mediated by extracellular vesicles. The International Society for Extracellular Vesicles 2019; Kyoto, Japan, April 24-28, 2019.
  21. 吳順成,陳崇桓, 陳振偉, 伍哲緯, 張瑞根*, 何美泠* Hyaluronan Microenvironment Enhances Chondrogenic, but Prevents Osteogenic, Effects of Simvastatin in Adipose Derived Stem Cells. Annual Meeting of Taiwan Orthopaedic Association中華民國骨科醫學會107年度第75次聯合學術研討會 October 27-28, 2018.
  22. Ming Wei HUNG, Chigoko WATANABE, Kazuki YOSHIDA, Che Wei, WU, Shigeki YOSHIDA, Hitoshi MIYAZAKI. Effects of resveratrol and E-viniferin on adipocyte differentiation and adiponectin protein expression in 3T3-L1 preadipocytes. ISNFF P25. Orlando, FL, USA, 2016.
  23. Mayo HADANO, Mayuko OSA, Che Wei WU, Hitoshi MIYAZAKI. Role of polyamines in the regular of Srituin 1. Ag-ESD Symposium, Japan, 2015.
  24. Tsubasa IKEYA, Chigako WATANABE, Ming Wei HUNG, Che Wei WU, Shigeki YOSHIDA, Denbei KAWAMURA, Hitoshi MIYAZAKI. Function of “Teadenol,” a New Polyphenol Compound Extracted from a Tea Leaf Fermented by Aspergillus PK-1. Ag-ESD Symposium, Japan, 2015. 
  25. Wu Che Wei, Zrelli H, Hung MW, Yoshida S, Hatano M, Osa M, Miyasaki H. Comparative study on the functions of the red wine compounds resveratrol and its dimer epsilon-viniferin. The 37th Annual Meeting of the Molecular Biology Society of Japan, Japan, 2014

研究計畫：
  1. 2025/9  探討華通氏膠質間質幹細胞之細胞外囊泡對老化關節軟骨細胞抗氧化能力與粒線體功能之影響

其他：