National Chiayi University

Course Instruction
Human nutrition, Disease and therapeutic nutrition, Nutritional immunology, Functionality evaluation of health food.

Selected Publication

1. Lien, Y-C, Lin, S-M, Nithipongvanitch, R, Oberley TD, Noel, T, Zhao, Q,  Daosukho, C, St. Clair, DK. TNF receptors suppress the Fas-mediated pathway and protect against Adriamycin-induced mitochondrial injury in cardiac tissues.  Molecular Cancer Therapeutics. 2006:5(2):261-269
   
2. Daosukho C, Ittarat W , Lin, S-M, Sawyer, D B, Kiningham, K, Lien Y-C , St Clair, D K. Induction of Manganese Superoxide Dismutase (MnSOD) Mediates Cardioprotective Effect of Tamoxifen (TAM). Journal of Molecular and Cellular Cardiology. 2005;39:792-803
3. Zhao, Y, Wang, L-M, Chaiswing, L, Yen, H-C, Oberley, TD2, Lien, Y-C, Lin, S-M,. Mattson MP and St. Clair, DK. Tamoxifen Protects against Acute TNFa-Induced Cardiac Injury via Improving Mitochondrial Functions. Free Radical Biology and Medicine. 2006;40(7):1234-41
4. Cole, M.P, Chaiswing, L., Oberley, TD, Edelmann, SE., Piascik, MT., Lin, S-M., Kiningham, KK., St Clair, DK. The protective role of nitric oxide and superoxide dismutase in adriamycin-induced cardiotoxicity. Cardiovascular Research. 2006;69:186-197.
5. Zhao, Y, Oberley,  T.D., Chaiswing, L, Lin,  S.M , Epstein, C J, Huang,  TT, St Clair,  DK. Manganese superoxide dismutase deficiency enhances cell turnouver via tumor promoter-induced alterations in AP-1 and p53-mediated pathways in a skin cancer model. Oncogene  2002 ;21:3836-3846
6. Zhao, Y, Xue Y, Oberley, TD, Kiningham, KK, Lin, S.M.,  Yen, HC, Majima, H, Hines, J, St Clair, D. Overexpression of manganese superoxide dismutase suppresses tumor formation by modulation of activator protein-1 signaling in a multistage skin carcinogenesis model. Cancer Res 2001 61(16):6082-8
7. Zhao, Y, Kiningham KK, Lin, S.M.., St Clair, DK. Overexpression of MnSOD protects murine fibrosarcoma cells (FSa-II) from apoptosis and promotes a differentiation program upon treatment with 5-azacytidine: involvement of MAPK and NFkappaB pathways. Antioxid Redox Signal 2001 Jun; 3(3): 375-86 

 
Conference Abstract

1. Daosukho C, Lin S-M, Kiningham K, and St. Clair DK. MnSOD expression protects against adriamycin induced cardiac injury. Society of Free Radical Biological Medicine 2003 10th Annual Meeting, Seattle, WA, USA
2. Zhauo Y, Wang L-M, Chaiswing L, Oberley DT, Lin S-M and St. Clair DK. Tamoxifen proects against TNF--induced mitochondrial dysfunction in cardiac tissues. 2002. 9th Annual Meeting of American Association for Cancer Research,Washington, DC, USA.
3. Cole M P, Oberley T, Lin S-M, Kiningham K K, St Clair D K. Loss adaptive response to oxidative stress and exacerbation of ADR-induced cardiac injury in iNOS homozygous knockout mice. 8th Annual Meeting of the Oxygen Society,November 15-19, 2001, Research Triangle Park, NC, USA.
4. Lin S-M, Wang  LM, Kiningham KK, St Clair DK. Exacerbation of TNF and the protection of MnSOD in adriamycin-induced cardiac injury. 7th Annual Meeting of the Oxygen Society, November 16-20, 2000,San Diego, CA, USA.