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National Chiayi University
:::

Lu Ying Chen, Ph. D.


Lu Ying Chen , Associate professor

Ph. D., The Department of Life Sciences,NTHU
Course Instruction: Probiotics, Fermentation, Enzymes
Tel：+886-5-2717615
E-mail:biolyc@mail.ncyu.edu.tw

Ph. D.,


期刊論文： 

  1. Chen CC, Lai CC, Huang HL, Huang WY, Toh HS, Weng TC, Chuang YC, Lu YC*, Tang HJ*. Antimicrobial Activity of Lactobacillus Species Against Carbapenem-Resistant Enterobacteriaceae. Front Microbiol. 2019 Apr 18;10:789. doi: 10.3389/fmicb.2019.00789.
  2. Lai CC, Chen CC, Lu YC, Chuang YC, Tang HJ. In vitro activity of cefoperazone and cefoperazone-sulbactam against carbapenem resistant Acinetobacter baumannii and Pseudomonas aeruginosa. Infection and Drug Resistance 2019:12 25–29. Doi:10.2147/IDR.S181201.
  3. Lai CC, Chen CC, Lu YC, Chen HJ, Su BA, Weng TC, Chiu YH, Toh HS, Zhang CC, Chiang SR, Chuang YC, Tang HJ. Simultaneous three Enterobacteriaceae with different bla NDM-1-encoding plasmids in a patient transferred from mainland China to Taiwan. Infect Drug Resist. 2018 Dec 2018:11 2555–2560. Doi: 10.2147/IDR.S179024. eCollection 2018.
  4. Lai CC, Chen CC, Lu YC, Lin TP, Chuang YC, Tang HJ. Appropriate composites of cefoperazone-sulbactam against multidrug-resistant organisms. Infect Drug Resist. 2018 Sep 11; 11:1441-1445. doi: 10.2147/IDR.S175257. eCollection 2018.
  5. Lai CC, Chen CC, Lu YC, Chuang YC, Tang HJ. The clinical significance of silent mutations with respect to ciprofloxacin resistance in MRSA. Infect Drug Resist. 2018 May 3;11:681-687. doi: 10.2147/IDR.S159455. eCollection 2018.
  6. Chang PC, Chen CC, Lu YC, Lai CC, Huang HL, Chuang YC, Tang HJ. The impact of inoculum size on the activity of cefoperazone-sulbactam against multidrug resistant organisms. J Microbiol Immunol Infect. 2018 Apr;51(2):207-213. doi: 10.1016/j.jmii.2017.08.026. Epub 2017 Oct 6.
  7. Jhan JK, Chung YC, Chen GH, Chang CH, Lu YC, Hsu CK. (2016) Anthocyanin contents in the seed coat of black soya bean and their anti-human tyrosinase activity and antioxidative activity. Int J Cosmet Sci. 38(3):319.
  8. 呂英震、蘇莉雅、楊翰彬、許洪睿、朱紀實、羅至佑 (2016) 大豆 (金珠 )十石優格於發酵製程異黃酮及嘌呤之成分變化。嘉義大學農林學報 13卷 2期
  9. 李勝箖、陳怡文、吳峻瑋、謝鈞任、馬雅均、朱紀實、羅至佑、呂英震 (2016)篩選以大豆為發酵基質生產血管收縮素轉換 酶 抑制能力最佳之乳酸菌株。嘉義大學農林學報 13卷 1期
  10. Hsieh FC, Lee CL, Chai CY, Chen WT, Lu YC, Wu CS. (2013) Oral administration of Lactobacillus reuteri GMNL-263 improves insulin resistance and ameliorates hepatic steatosis in high fructose-fed rats. Nutr Metab (Lond). 10(1):35.
  11. Lu, Y.C.* , Hsieh, F.C., Lee, C.L., (2012) Characterization of Lactobacillus rhamnosus GMNL-74 (GM020), a potential probiotic bacterium with cholesterol-lowering effects. (submitted FOOD-D-11-00769R1)
  12. Wang, H.F., Tseng, C.Y., Chang, M.H., Lin, J.A., Tsai, F.J., Tsai, C.H., Lu, Y.C., Lai, C.H., Huang, C.Y., and Tsai, C.C. (2012) Anti-Inflammatory Effects of Probiotic Lactobacillus paracasi on Ventricles of BALB/C Mice Treated with Ovalbumin. Chin J Physiol. 55(1): 37. (SCI, IF=0.683, Q4)
  13. Lu, Y.C. , Yin, L.T., Chang, W.T., and Huang, J.S. (2010) Effect of Lactobacillus reuteri GMNL-263 treatment on renal fibrosis in diabetic rats. J Biosci Bioeng. 110(6): 709 (SCI, IF=1.749, Q2)
  14. Yin, L.T., Lin, Y.T., Leu, Y.C. and Hu, C.Y. (2010) Enzyme immobilization on nitrocellulose film for pH-EGFET type biosensors. Sensors & Actuators: B. Chemical, 148 (1): 207 (SCI, IF=3.370, Q1)
  15. Huang, H.C., Wang, S.C., Leu, Y.J., Lu, S.C. and Liao, Y.D. (1998) The Rana catesbeiana rcr gene encoding a cytotoxic ribonuclease. Tissue distribution, cloning, purification, cytotoxicity, and active residues for RNase activity. J Biol Chem 273(11): 6395-6401 (SCI 6.355)
  16. Liao, Y.D., Huang, H.C., Leu, Y.J., Wei, C.W., Tang, P.C. and Wang, S.C. (2000) Purification and cloning of cytotoxic ribonucleases from Rana catesbeiana (bullfrog). Nucleic Acids Res 28(21): 4097-4104 (SCI 7.260)
  17. Hsu, C.H., Liao, Y.D., Pan, Y.R., Chen, L.W., Wu, S.H., Leu, Y.J. and Chen, C. (2003) Solution Structure of the Cytotoxic RNase 4 from Oocytes of Bullfrog Rana catesbeiana. J Mol Biol 326(4): 1189-1201 (SCI 5.542)
  18. Leu, Y.J. , Chern, S.S., Wang, S.C., Hsiao, Y.Y., Amiraslanov, I., Liaw, Y.C. and Liao, Y.D. (2003) Residues Involved in the Catalysis, Base Specificity, and Cytotoxicity of Ribonuclease from Rana catesbeiana Based upon Mutagenesis and X-ray Crystallography. J Biol Chem 278(9): 7300-7309 (SCI 6.355)
  19. Liao, Y.D., Wang, S.C., Leu, Y.J., Wang, C.F., Chang, S.T., Hong, Y.T., Pan, Y.R. and Chen, C. (2003) The structural integrity exerted by N-terminal pyroglutamate is crucial for the cytotoxicity of frog ribonuclease from Rana pipiens. Nucleic Acids Res 31(18): 5247-5255 (SCI 7.260)

研討會論文： 

  1. 蘇莉雅、謝佩真、呂英震、羅至佑 (2016) 市售大豆及豆渣之產品開發與異黃酮含量分析。第三次大豆高加價值產品研發研討會
  2. Hsin-Yu Huang, Meei-Yn Lin, Wei-Hsun Chao, Wen-Fu Wu, Hui-Ling Chen, Ying-Chen Leu. (2014) Different fermentation times of Pediococcus pentossceus LYC 791on soybeans: Impact on its antioxidant capacity. 17th Buennial Meeting of Society for Free Radical Research International
  3. Ying-Chen Leu , Hsin-Yu Huang, Ku-Hsien Lai, Yen-Ching Hsiao, Yi-Heng Chiu, Meei-Yn Lin. (2014) In vitro antioxidant properties and phenolic composition of black soybeans fermented with Weissilla cibaria LYC 721. 17th Buennial Meeting of Society for Free Radical Research International
  4. HL. Chen and YC Lu. (2014) Effect of aromatic rice content on the coagulation and stability of set soy-yogurt. 12th Interantional Hydrocolloids Conference
  5. Su, K.H., Chen, C.T., Lu, Y.J., Hsieh, S.L., Wu, C.C. (2012) Inhibition of Gynura bicolour on transmigration in human endothelial cells. International conference and exhibition on nutraceuticals and functional foods 2012, Hawaii, USA (P185)
  6. 謝豐欽、李佳玲、呂英震 (2012) Lactobacillus reuteri ADR-1 乳酸菌在 Streptozotocin (STZ) 誘發糖尿病大鼠之血糖以及血脂值改善的效果。台灣保健食品學會 2012 年會 (PA108)
  7. 黃兆尉、蔡昌嶧、呂英震 (2012) 不同中草藥發酵對乳酸菌生長及細菌素生產之影響。台灣保健食品學會 2012 年會 (PA109)
  8. Hsieh, S.L., Kuo, Y.L., Lu, Y.C., Hsieh, L.C. and Wu, C.C. (2012) Suppression of Gynura bicolor (Roxb.) ether extract on ICAM-1 expression in SD rat fed a high fat diet. 台灣保健食品學會 2012 年會 (PA061)
  9. 黃璻尹，呂英震 , (2011) 開發水產養殖用乳酸菌抑菌素。 2011 保健產品趨勢研討會暨專題海報競賽 , 教育部生技保健產品開發聯合技術發展中心
  10. 黃兆尉，呂英震 , (2011) 開發食品防腐用乳酸菌抑菌素。 2011 保健產品趨勢研討會暨專題海報競賽 , 教育部生技保健產品開發聯合技術發展中心
  11. Hsieh, F.C., Lee, C.L., Lu, Y.C. (2011) Effect of Lactobacillus reuteri GMNL-263 on improvement of glucose intolerance and lipid profile in high fructose fed rat. 乳酸菌年會
  12. Yu, C.H., Wu, C.C., Hsieh, S.L., Hsieh, F.C., Li, Y.C., Lu, Y.C., (2010) Effects of lactobacilli on acute colitis in C57BL/6 mice. 益生菌與嬰兒疾病學術與產業應用研討會 , 乳酸菌年會
  13. Hsieh, F.C., Lee, V.L., Li, Y.C., Lu, Y.C. (2010) The Effect of Oral Lactobacillus Contain Resveratrol on Suppressed Allergic Responses in an Ovalbumin-induced Allergy Mouse Model. 臺灣保健食品學會 2010 年會員大會暨保健食品與痛風研討會
  14. Hsieh, F.C., Li, Y.C., Lee, C.L., Lu, Y.C. (2010) Immune modulation effects of Lactobacillus fermentumGM-090 mediated by modulation of Th1/Th2 immunoregulation. 乳酸菌年會
  15. 江冠勳 , 謝惠如 , 黃兆尉 , 呂英震 (2010) 乳酸菌對抗陰道病原菌能力分析臺灣保健食品學會 2010 年會員大會暨保健食品與痛風研討會
  16. 蔡沛蓁 , 謝惠如 , 黃兆尉 , 呂英震 (2010) 乳酸菌於發酵蔬菜防腐作用。臺灣保健食品學會 2010 年會員大會暨保健食品與痛風研討會
  17. 黃兆尉 , 謝惠如 , 呂英震 (2010) 益生菌抗菌蛋白分析。臺灣保健食品學會 2010 年會員大會暨保健食品與痛風研討會
  18. Lin, S.Y., Li, Y.C., Hsu, X.Y., Yang, H.O., Lu, Y.C. (2009) Probiotic Dental-Lac (Lactobacillus paracaseiGMNL-33) effect on periodontal pathogens and dental caries risk factors. 5th Asian Conference for Lactic Acid Bacteria. Singapore
  19. Hsieh, F.C., and Lu, Y.C. (2008) Effect of Oolong tea contains Lactobacillus paracasei AAP-1 on anti-allergy. 台灣食品科技年會 (PE-008)
  20. Hsieh, F.C., Chang, C.K., and Lu, Y.C. (2008) The Effects of Lactobacillus reuteri ARA-1 on Ameliorate experimental collagen-induced arthritis in rats. 『發酵乳的無可取代的價值』學術研討會暨台灣乳酸菌協會 97 年度會員大會
  21. Lu, Y.C. , Liu, Y.T., and Yu, T.W. (2007) Safety assessment of Lactobacillus paracasei AAP-1. 4th Asian Conference for Lactic Acid Bacteria. Shanghai, China
  22. Lin, W.H., Lu, Y.C., Hsieh, F.C., and Yu, T.W. (2007) The effect of Lactobacillus rhamnosus CLR-1TM on serum cholesterol levels in hamsters fed high-cholesterol diet. 4th Asian Conference for Lactic Acid Bacteria. Shanghai, China
  23. 李季螢 , 羅仕淦 , 呂英震 , 賴呈委 . (2005) 護元茶對 BALB/c 小鼠非特異性免疫功能調節之影響 . Global Chinese symposium on health foods in 2005. Taipei, Taiwan (Poster PC-2)
  24. 李季螢 , 羅仕淦 , 呂英震 , 賴呈委 . (2005) 以四氯化碳肝損傷模式評估保青茶護肝功能 . Global Chinese symposium on health foods in 2005. Taipei, Taiwan (Poster PF-1)
  25. Leu, Y.J. , Wang, S.C., Huang, H.C., Lu, S.C., and Liao, Y.D. (1998) The Rana catesbeiana rcr gene encoding a cytotoxic ribonuclease (RC-RNase): cloning, purification, cytotoxicity and active residues for RNase activity. The thirteen joint annual conference of biomedical sciences. Taipei, Taiwan (Oral Presentation 39)
  26. Leu, Y.J. , Wang, S.C., Wei, C.W., and Liao, Y.D. (2000) Characterization of cytotoxic ribonucleases from Rana catesbeiana (bullfrog). Eighth symposium on recent advances in cellular and molecular biology. PingTung, Taiwan (Poster P53)

專利：

  1. ( 發明 ) 呂英震 、翁博群，預防或減緩糖尿病及其併發症的大豆醱酵產物及其應用， TW
  2. ( 發明 ) Tu-Wen Yu, Jun-Sheng Li, Fen-Ching Hsieh, Ching-Pei Chen, Tsuei-Yin Huang, Ying-Chen Lu, "Lactobacillus Isolates Having Anti-Inflammatory Activities and Uses of the Same" US 7901926
  3. ( 發明 ) Ching-Hsiang Hsu, and Ying-Chen Lu, " Microorganism strain GM-090 of Lactobacillus fermentum and its use for stimulating IFN-gamma secretion and/or treating allergy", US7351572
  4. ( 發明 ) Tu-Wen Yu, Jun-Sheng Li, Fen-Ching Hsieh, Ching-Pei Chen, Tsuei-yin Huang, Ying-Chen Lu, "Lactobacillus Isolates Having Anti-Inflammatory Activities and Uses of the Same (GMNL-76)" EP2116594
  5. ( 發明 ) Ching-Hsiang Hsu, and Ying-Chen Lu, " NEW MICROORGANISMAL STRAIN GM-090 OF LACTOBACILLUS FERMENTUM, AND ITS USE FOR STIMULATING IFN-gamma SECRETION AND/OR TREATING ALLERGY ", JP4823503
  6. ( 發明 ) Du Wen Yu, Jun Sheng Li, Feng Qin Xie, Liang Pei Chen, Zui Yin Huang, Ying Zhen Lu, "Lactobacillus separation strains with anti-inflammatory activity and application thereof (GMNL-76) ", 851562/CN101575582B
  7. ( 發明 ) Ching-Hsiang Hsu, and Ying-Chen Lu, " Microorganism strain GM-090 of lactobacillus fermentum and its use for stimulating INF-gamma secretion and/or treating allergy ", 337946/CN1329505C
  8. ( 發明 ) 呂英震 、黃昭祥、謝豐欽、李易丞、李佳玲，益生菌株 GM-263 (ADR-1) 用於治療糖尿病引發之腎纖維化的組合物及其用途。 I355939
  9. ( 發明 ) 俞篤文，李濬笙，謝豐欽，陳靚珮，黃璻尹，呂英震，具有抗發炎活性的乳桿菌分離株及其用途 (GMNL-89) ， I346554
  10. ( 發明 ) 呂英震 ，謝豐欽，新穎乳桿菌、其組合物、及彼等於改善糖尿病及其併發症之用途， I340021
  11. ( 發明 ) 許清祥、呂英震，新穎微生物株醱酵乳酸桿菌 GM-090 及其刺激 INF-g 分泌及 / 或治療過敏之用途， I319780 。
  12. ( 新型 ) 呂英震 ，林聖文， 具減緩心臟發炎功效之乳酸菌口服微粒結構， M405267
  13. ( 新型 ) 呂英震 ，謝豐欽，林聖文， 具減緩糖尿病症狀功效之乳酸菌口服微粒結構， M405270
  14. ( 新型 ) 呂英震 ，林聖文， 具牙齒保健功效之乳酸菌口服微粒結構， M405271
  15. ( 新型 ) 呂英震 ，謝豐欽，陳俐吟，林聖文， 女性保健用的口服微粒， M397903
  16. ( 新型 ) 呂英震 ，謝豐欽，陳俐吟，林聖文， 具有護肝功效的口服微粒， M396124
  17. ( 發明 ) Tu-Wen Yu, Jun-Sheng Li, Fen-Ching Hsieh, Ching-Pei Chen, Tsuei-yin Huang, Ying-Chen Lu, "Lactobacillus isolated strain having anti-inflammatory activity a nd use thereof" JP2009269906 (A)
  18. ( 發明 ) DuWen Yu, JunSheng Li, FengQin Xie, LiangPei Chen, ZuiYin Huang, YingZhen Lu, "Lactobacillus separation strains with anti-inflammatory activity and application thereof (GMNL-89) ", 201010567585.7  
  19. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "Novel  Lactobacillus Strain,Composition and Use Thereof for Improving the Syndrome of Diabetes and Complication Thereof", CN201010205942.5
  20. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "Novel Lactobacillus Strain,Composition and Use Thereof for Improving the Syndrome of Diabetes and Complication Thereof", EP10164646.1
  21. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "Novel Lactobacillus Strain,Composition and Use Thereof for Improving the Syndrome of Diabetes and Complication Thereof", JP2010-130974
  22. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "Novel Lactobacillus Strain,Composition and Use Thereof for Improving the Syndrome of Diabetes and Complication Thereof", US 12/792276
  23. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", CN201010276607.4
  24. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", DE102010060693.6
  25. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", FR1150235
  26. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", GB10199556.8
  27. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", JP2010-291410
  28. ( 發明 ) Ying-Chen Lu,   Ching-Hsiang Hsu, Cheng-Chih Tsai, Chih-Yang Huang, Hsueh-Fang Wang, Chien-Yu Tseng, "USE OF PROBIOTIC STRAIN GM-080 IN TREATING CARDIAC INFLAMMATION AND APOPTOSIS", US12/947829
  29. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, COMPOSITION AND USE OF LACTOBACILLUS PARACASEI STRAIN GMNL-133 IN TREATING ATOPIC DERMATITIS OR OTHER ALLERGIC DISEASES, US13/273,228
  30. ( 發明 ) Tu-Wen Yu, Jun-Sheng Li, Fen-Ching Hsieh, Ching-Pei Chen, Tsuei-yin Huang, Ying-Chen Lu, "Lactobacillus Isolates Having Anti-Inflammatory Activities and Uses of the Same (GMNL-89)" EP10191326.7
  31. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "COMPOSITION AND USE OF LACTOBACILLUS PARACASEI STRAIN GMNL-133 IN TREATING ATOPIC DERMATITIS OR OTHER ALLERGIC DISEASES", EP11185212.5
  32. ( 發明 ) Ying-Chen Lu, and Ching-Hsiang Hsu, "COMPOSITION AND USE OF LACTOBACILLUS PARACASEI STRAIN GMNL-133 IN TREATING ATOPIC DERMATITIS OR OTHER ALLERGIC DISEASES", CN
  33. ( 發明 ) Ying-Chen Lu,   Jau-Shyang Huang, Ching-Hsiang Hsu, Yi-Cheng Li, Chia-Lin Lee, "Composition and use of probiotic strain GM-263 (ADR-1) in treating renal fibrosis in diabetes." JP2011-19444
  34. ( 發明 ) Ying-Chen Lu,   Jau-Shyang Huang, Ching-Hsiang Hsu, Yi-Cheng Li, Chia-Lin Lee, "Composition and use of probiotic strain GM-263 (ADR-1) in treating renal fibrosis in diabetes." US13/006,432
  35. ( 發明 ) 俞篤文、李濬笙、謝豐欽、陳靚珮、黃璻尹、呂英震，具有抗發炎活性的乳桿菌分離株及其用途 (GMNL-76) ， TW100116515
  36. ( 發明 ) 呂英震 、謝豐欽， 副乾酪乳酸桿菌株 GM-133 用於改善異位性皮膚炎或其他過敏疾病之組合物及其用途 , TW100137219
  37. ( 發明 ) 呂英震 、謝豐欽、蔡政志、黃志楊、王雪芳、曾千育，益生菌株 GM-080 用於治療心臟發炎與心臟細胞凋亡之組合物及其用途， TW99129548