National Chiayi University

Education:

2003/2 Ph.D. Department of Chemistry & Biochemistry

        University of Delaware (Advisor: Prof.Charlie G. Riordan)
1996/6 B.S. Department of Chemistry

        National Changhua University of Education

Experiences:

2010/8- National Chiayi University Associate Professor

2004/8-2010/7 National Chiayi University Assistant Professor

2003/8-2004/7 National Tsing Hua University Postdoctoral

1996/8-1998/7 National Changhua University of Education

                Research Assistant

Research Area:

Bioinorganic/organicmetallic Chemistry

Metal biomedical materials

NO Release Agent for Repellent / Attraction of Mosquito Development of cosmetic materials

Location: Chemistry Building I, A17-303

Tel: 05-271-7951

E-mail: genechiou@mail.ncyu.edu.tw

Research Interests:

Publication:

1.    Chieh-Wei Chung, Bo-Wen Liao, Shu-Wei Huang, Show-JenChiou, Cheng HanChang, Sheng-JuLin, Bo-Hao Chen, Wei-Ling Liu, Shang-Hsiu Hu, Yu-Chun Chuang, Chia-Her Lin, I-Jui Hsu, Chao-Min Cheng, Chieh-Cheng Huang, and Tsai-Te Lu* Magnetic Responsive Release of Nitric Oxide from an MOF-Derived Fe3O4 @PLGA Microsphere for the Treatment of Bacteria-Infected Cutaneous Wound ACS Applied Materials and Interfaces 2022, 14(5), 6343-6357.

2.    Yun-Chieh Sung^1,2, Pei-Ru Jin¹, Li-An Chu³, Fu-Fei Hsu⁴, Mei-Ren Wang⁵, Chih-Chun Chang¹, Show-Jen Chiou⁶, Jiantai Timothy Qiu^7,8,9, Dong-Yu Gao¹, Chu-Chi Lin⁹, Yu-Sing Chen⁹, Yi-Chiung Hsu¹⁰, Jane Wang², Fu-Nien Wang¹¹, Pei-Lun Yu¹¹, Ann-Shyn Chiang ^3,12,13,14, Anthony Yan-Tang Wu^15,16,17, John Jun-Sheng Ko^1,15, Charles Pin-Kuang Lai ^15,16,18, Tsai-Te Lu ^1,5* Yunching Chen ¹*, Delivery of nitric oxide with a nanocarrierpromotes tumour vessel normalization and potentiates anti-cancer therapies. Nature Nanotechnology, 2019, 12, 1160-1169.

3.    Tsai-Te Lu^*,†, Yun-Ming Wang^*,‡, Chen-Hsiung Hung^*,§, Show-Jen Chiou*, Wen-Feng Liaw*, Bioinorganic Chemistry of the Natural Fe(NO)₂ Motif: Evolution of a Functional Model for NO-Related Biomedical Application and Revolutionary Development of a Translational Model. Inorg Chem, 2018, 57, 12425-12443.

4.    Tsai-Te Lu, Hsiao-Wen Huang, Chia-Her Lin, Yu-Ting Tseng, Wen-Feng Liaw, Hsi-Ya Huang, Show-Jen Chiou “DINITROSYL IRON COMPLEX, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, COMPOSITE MATERIAL COMPRISING THE SAME, AND USES THEREOF” U.S. Patent Application No. 15/413,428, January 24, 2017.

5.    Show-Jen Chiou; Yu-Der Wen, " Effects of curcumin on nitrosyl-iron complex-mediated DNA cleavage and cytotoxicity. Rong-Jen Shiau, Jheng-Yu Wu,," Planta Med, 2012, 78, 1342-1350.

6.    Show-Jen Chiou ¹, Arnold L. Rheingold ², Glenn P.A. Yap, Charles G. Riordan,  Coordination chemistry of pyrazolylbis((alkylthio)methyl)borates: Hybrid nitrogen and sulfur donor ligands,  Inorganica Chimica Acta., 2010, 364, 81-88.

7.    Chien-Hong Chen*, Show-Jen Chiou,*,and Hsuan-Yin Chen, Dinuclear [{Fe(NO)2}10-{Fe(NO)2}10] Dinitrosyl Iron Complex with Thiolate-CO-Bridged Ligands, Inorg. Chem., 2010, 49, 2023-2025.

8.    Yu-Der Wen, Yun-Lung Ho, Rong-Jen Shiau, Jung-Kai Yeh, Jheng-Yu Wu, Wei-Lung Wang, Show-Jen Chiou*, Synergistic antitumor effect of curcumin and dinitrosyl iron complexes for against melanoma cells, J. Organomet Chem., 2010, 695, 352.

9.     H.-H. Chang; H.-J. Huang; Y.-L. Ho; Y.-D. Wen; W.-N. Huang; S.-J. Chiou*.The water-soluble Roussin’s red ester acting as a potential photochemical NO-delivery agent: Photolysis reactions, DNA cleavage and anticancer activity. Dalton Trans, 2009, 6396.

10.  S.-J Chiou*; C.-C. Wang, C.-M. Chang, Synthesis of dinitrosyl iron complexes (DNICs) with intramolecular hydrogen bonding. JOMC, 2008, 693, 3582.

Lab members: