National Chiayi University

‧ Synthesis of potential anticoagulant drugs

1.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, 1992, " Synthesis Of Substituted Malonic Acids from Carbon Radicals" , Tetrahedron Lett. , 33, 7299-7302.

2.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, 1992, " Two Carbon Homologation Of Carboxylic Acids" , Tetrahedron Lett. , 33, 5017-5020.

3.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, 1992, " Homologation Of Carboxylic Acids By Improved Method Based On Radical Chain Chemistry" , Tetrahedron Lett. , 33, 5013-5016.

4.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, T. Shinada, 1993, " Chain-Elongation and Degradation of Carboxiic Acids by Barton-Ester Based Radical Chemistry" , Tetrahedron Lett. , 34, 6505-6508.

5.      D. H. R. Barton, C. Y. Chern, C. Tachdjian, 1994, "Ration Of New Thiohydroxamic Derivatives; Synthesis of Substituted l-Hydroxy-l,2-Dihydroimidazole-2-Thiones" , Heterocycles , 37, 793-805.

6.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, 1995, " The Invention Of Radical Reactions. Part XXXIV. Homologation 　Of Carboxylic Acids to a Keto Carboxylic Acids by Barton-Ester Based Radical Chain Chemistry" , Tetrahedron , 51, 1867-1886.

7.      D. H. R. Barton, C. Y. Chern, J. Cs. Jaszberenyi, 1995, " The Invention Of Radical Reactions. XXXIII Homologation Reactions Of Carboxylic Acids By Radical Chain Chemistry", Aust. J. Chem. , 48, 407-425.

8.      S. J. Wu, I. S. Chen, C. Y. Chern, C. M. Tseng, T. S. Wu, 1996, " Structure And Synthesis of Simulansamide, A Platelet Aggregation Form Zanthoxylum Simulans", J. Chin. Chem. Soc. , 43,195.

9.      T. S. Wu, Y. Y. Chan, Y. L. Leu, C. Y. Chern C. F. Chen, 1996, " Cytotoxic Principles From Nothapodytes Foetida(ll) Nothapodytine A and B Two New Alkaloids from Nothapodytes Foetida", Phytochemistry, 42, 907.

10.  T. S. Wu, L. S. Shi, S. C. Kuo, C. Y. Chern, S. F. Tung, C. M. Teng, 1997, "Platelet Aggregation Inhibitor from Gamoderma Lucidum", J Chin Chem. Soc. , 44, 157.

11.  T. S. Wu, Y. C. Wu, P. L. Wu, C. Y. Chern, Y. L. Leu, Y. Y. Chan, 1998, “ Structure and Synthesis of [n]-Dehydroshogaols from Zingiber officinale ” , Phytochemistry , 48 , 889.

12.  T. S. Wu, H. C. Hsu, P. L. Wu, Y. L. Leu, Y. Y. Chan, C. Y. Chern, M. Y. Yeh, H. J. Tein, 1998, “ Naphthoquinone Esters from the root, of Rhinacanthus nasutus ” , Chem. Pharm. Bull. , 46, 413.

13.  W. M. Kan, C. Y. Chem, S. F. Su, 1998, "Synthesis of l-(2-Carboxyethylbenzyl)- 2-benzenesulfonamidobicyclo[ 2.2.1 ]heptane: A Novel Potent Thromboxane Antagonist", J. Chin. Chem. Soc ., 45, 711.

14.  陳清玉 , 2000, “ 九二一震災後化學實驗室安全的省思 ” , Chemistry, 58, A10-A12.

15.  C. Y. Chern, Y. L. Yek, J. D. Jan, W. M. Kan, 2001, “ Synthesis of the chair Pair of a Novel Thromboxane Antagonist, 3-[2-(3-Benezenesulfonylamino-7-oxabicyclo [2,2,2]hept-2-yl-methyl)phenyl]propionic Acid ” , J. Chin. Chem. Soc ., 48, 　907-912.

16.  C. Y. Chern, Y. P. Huang, W. M. Kan, 2003, “ Selective N -debenzylation of Amides with p -TsOH. ” , Tetrahedron Lett ., 44, 1039-1041.

17.  W. M. Kan, Y. L. Yek, Y. H. Wang, C. Y. Chern, 2003, “ Synthesis of 4-Aza-3-oxo- androstane-17 b -carboxylic Acid, a Key Intermediate for the Preparation of Potent 5 a -Reductase Inhibitors ” , Chin. Pharm. J. 55 , 213-219.

18.  W. M. Kan, C. L. Cheng, C. Y. Chern, 2004, “ One-Pot Synthesis of Ene-Lactams via N -Debenzylation of Keto-　Containing N -2,4-Dimethoxyylbenzylamides ” , Synth. Commun. 34 , 4257-4264.

19.  C. Y. Chern , S. J. Chen, W. M. Kan, 2005, “ Design and Synthesis of 3-Aryl-5-Alicyclic-[1,2,4]-oxadiazoles as Novel Platelet Aggregation Inhibitors ” , J. Chin. Chem. Soc . 52 , 331-338.

20.  洪巧珍 , 陳家鐘 , 陳清玉 , 彭淑貞 , 莊益源 , 陳昇寬 , 王文哲 , 蔡恕仁 , 李木川 , 顏辰鳳 , 洪銘德 , 2005 “ 楊　桃花姬捲葉蛾性費洛蒙產品與應用 ”, Formosan Entomol. Spec. Pub. 7 , 29-58.

21.  W . M. Kan, S. H. Lin , C. Y. Chern, 2005, “ Efficient Synthesis of 2-( N -Substituted)-2-imidazolines and 2-( N -Substituted)-1,4,5,6-tetrahydropyrimidines ” , Synth. Commun. 35, 2633-2639.

22.  T. L. Hwang, S. H. Yeh, Y. L. Leu, C. Y. Chern, H. C. Hsu, 2006,“Inhibition of superoxide anion and elastase release in human neutrophils by 3’-isopropoxychalcone via a cAMP-dependent pathway”, Br. J. Pharmacol. 148, 78-87.

23.  H. W. Shen, Y. L. Chen, C. Y. Chern, W. M. Kan, 2007, “The effect of prostacyclin agonists on the differentiation of phorbol ester treated human erythroleukemia cells”, Prostaglandins and other Lipid Mediators (accepted).

24.  C. Y. Chern, Y. L. Yek, Y. L. Chen, W. M. Kan, 2008, “Synthesis of 2-[4-(Imidazolin-2-ylideneamino)benzyl]-indan-1-ones as Novel Potent Prostacyclin Antagonists”, J. Chin. Chem. Soc.

25.  S. L. Wang, J. M. Lin, S. E. Shu, C. Y. Chern, 2010, “Influences of protonation and hydrogen bonding on intramolecular charge transfer compounds possessing different spacers”, J. Photochem. Photobiol. A: Chem.

26.  H. Chen ,* W. H. Wang , Y. H. Wang , Z. Y. Lin , C. C. Wen, C. Y. Chern * , 2013, “Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model”, molecule 18, 2052-2060.

27.  Y. T. Lee, T. H. Fong ,H. M. Chen ,C. Y. Chang ,Y. H. Wang ,C. Y. Chern ,* and Y. H. Chen * , 2014, “Toxicity Assessments of Chalcone and Some Synthetic Chalcone Analogues in a Zebrafish Model”, molecule 19, 641-650.

28.  H. C. Shih, C. Y. Chern, P. C. Kuo, Y. C. Wu, Y. Y. Chan, Y. R. Liao, C. M. Teng and T. S. Wu, 2014, “Synthesis of Analogues of Gingerol and Shogaol, the Active Pungent Principles from the Rhizomes of Zingiber officinale and Evaluation of Their Anti-Platelet Aggregation Effects”, International Journal of Molecular Sciences 15, 3926-3951.

29.  陳清玉, 2015, “Pro-Angiogenic Effects of Chalcone Derivatives in Zebrafish Embryos in Vivo”, Molecules 20, 12512-12524.