國立嘉義大學

張志成 Chang, Chih-Cheng

教授

最高學歷：美國愛荷華州立大學獸醫學院博士

MAIL：ccchang@mail.ncyu.edu.tw

電話：05-2732958

傳真：05-2732917

國立嘉義大學獸醫學系教授 (2020/08迄今

國立嘉義大學獸醫學系副教授 (2011/08-2020/07)

國立嘉義大學獸醫學系助理教授 (2004/08-2011/07)

國立嘉義大學農學院附設動物醫院院長 (2007/08-2010/07)

財團法人台灣動物科技研究所動物醫學組副研究員 (2002/09-2004/07)

美國愛荷華州立大學獸醫診斷實驗室博士後研究員 (2001/08-2002/07)

財團法人臺灣養豬科學研究所病理生物系助理研究員 (1994/02-1995/12)

台灣養豬科學研究所研究助理 (1986/10-1990/09 | 1992/07-1994/01)

專長

豬病學、獸醫病毒學、獸醫病理學、病毒演化學、動物疾病診斷

豬病學、豬生產醫學、獸醫病毒學、高等獸醫呼吸道疾病學、高等獸醫消化道疾病學

豬病生產醫學、動物病毒演化、動物疾病致病機轉、動物疾病田間疫情調查

期刊論文

1.        Pang VF, Chiang CF, Chang CC. 2020. The in vitro effects of aflatoxin B1 on physiological functions of swine alveolar macrophages. Veterinary Medicine and Science. 6 (4): 919-925. (SCI) (IF: 0.943, 74/141, 2018)

2.        Chiang CF, Yen CH, Chang CC. 2020. Evaluation on the Efficacy of a Porcine Reproductive and Respiratory Syndrome Virus Subunit Vaccine in Field Nursery Pigs. Journal of International Cooperation 15(1):xx-xx (2020-04-24 accepted).

3.        Yu CH, Cheng TY, Chiang CF, Chang CC. 2019. Effects of a live porcine reproductive and respiratory syndrome virus (PRRSV) vaccine on the growth performance, antibody response, and infection of common pathogens in field pigs. Journal of International Cooperation 14(2):83-98.

4.        Yu CH, Kaewprom K, Chang CC, Chiou MT, Lin CN. 2019. Genetic evolution of porcine reproductive and respiratory syndrome virus based on ORF5 on 7 Taiwanese pig farms. Thai Journal of Veterinary Medicine 49(2):167-174. (SCI) (IF: 0.318, 116/141, 2018)

5.        Yu CH, Chen CY, Chang CC. 2019. The immediate effects of weaning stress on the hypothalamus-pituitary‐adrenal alteration of newly weaned piglets. Journal of Animal Physiology and Animal Nutrition 103:1218-1223. (SCI) (IF: 1.703, 34/141, 2018)

6.        Hsu YH, Chou SJ, Chang CC, Pan MJ, Yang WC, Lin CF, Chan KW. 2017. Development and validation of a new loop-mediated isothermal amplification for detection of pathogenic Leptospira species in clinical materials. Journal of Microbiological Methods 141:55-59. (SCI) (IF: 1.803, 104/133, 2018)

7.        Xue YJ, Chang CC, Lai JM, Wang JH. 2017. Determining the tranquilization dose and residue of tricaine methanesulfonate (MS-222) in sea bass Lates calcarifer tissue. Fisheries Science 83(4):625-633.  (SCI) (IF: 0.929, 37/52, 2018)

8.        Lee Y, Lin CM, Jeng CR, Chang HW, Chang CC, Pang VF.2015. The pathogenic role of torque teno sus virus 1 and 2 and their correlations with various viral pathogens and host immunocytes in wasting pigs. Veterinary Microbiology 180:186-195. (SCI) (IF: 2.791, 7/141, 2018)

9.        Chiou MT, Yu CH, Chang CC, Chung WB, Wu HY, Lin CF, Lin CN.2014. Molecular characterization of the porcine epidemic diarrhea virus TW4/2014 in Taiwan. Austin Virology and Retrovirology 1(2): 1-4.

10.     Chan KW, Ping TY, Chou SJ, Zheng ZJ, Yang WC, Lai JM, Lo DY, Chang CC, Wu JT. 2014. Case Report: Treatment of an elderly dog with concurrent heart disease and acute uremia by hemodialysis. Taiwan Veterinary Journal 40(2):95-100.

11.     Tsai YC, Jeng CR, Chang CC, Hsiao SH, Chang HW, Lin CM, Chia MY, Wan CH, Pang VF. 2014. Differences in the expression of innate immune response-modulating genes in blood monocytes between subclinically porcine circovirus type 2 (PCV2)-infected and PCV2-free pigs prior to and after lipopolysaccharide stimulation in vitro. Taiwan Veterinary Journal   40(1):37-48.

12.     Karuppannan AK, Qiang J, Chang CC, Kwang J. 2013. A novel baculovirus vector shows efficient gene delivery of modified porcine reproductive and respiratory syndrome virus antigens and elicits specific immune response. Vaccine 31:5471-5478. (SCI) (IF: 3.485, 35/124, 2014)

13.     Chan KW, Ping TY, Chou SJ, Zheng ZJ, Yang WC, Lai JM, Lo DY, Chang CC, Wu JT. 2013. Case Report: Treatment of an elderly dog with concurrent heart disease and acute uremia by hemodialys. Taiwan Veterinary Journal 39(3):150-157.

14.     Lin CM, Jeng CR, Liu JP, Lin EC, Chang CC, Huang YL, Tsai YC, Chia MY, Wan CH, Pang VF. 2013. Immune gene expression profiles in swine inguinal lymph nodes with different viral loads of porcine circovirus type 2. Veterinary Microbiology 162:519-529. (SCI) (IF: 2.791, 7/141, 2018)

15.     Chiu SC, Hu SC, Chang CC, Chang CY, Huang CC, Pang VF, Wang FI. 2012. The role of porcine teschovirus in causing diseases in endemically infected pigs. Veterinary Microbiology 161:88-95.  (SCI) (IF: 2.791, 7/141, 2018)

16.     Huang PC, Chang CC, Kuo TY, Yang TS, Lee DN. 2011. Effects of diet supplemented with lingzhi culture on the growth and immune responses of weaned pigs. J. Chin. Soc. Anim. Sci. 40(4):221-231.

17.     Lo DY, Chen HY, Tee KY, Tseng YS, Wang KT, Tsai HP, Chiou HY, Hsiao SH, Chang CC, Wu JT. 2011. Case Report: Pyogranulomatous gastritis caused by pythium insidiosum in a dog. Taiwan Veterinary Journal 37(2):129-135.

18.     Lin CM, Jeng CR, Hsiao SH, Liu JP, Chang CC, Chiou MT, Tsai YC, Chia MY, Pang VF. 2011. Immunopathological characterization of porcine circovirus type 2 infection-associated follicular changes in inguinal lymph nodes using high-throughput tissue microarray. Veterinary Microbiology 149(1-2):72-84. (SCI) (IF:3.327, 2/145,2011)

19.     Chang CC, Huang AJ, Shyu BR, Ma WJ, Pang VF, Wang Jh. 2011. Epidemiological survey of torque teno virus (TTV) in Taiwan pig farms from 2008 to 2009. Taiwan Veterinary Journal 37(1):45-52.

20.     Shen SY, Ma WJ, Yu CY, Chang CC. 2010. Genetic variation of porcine reproductive and respiratory syndrome viruses in Taiwan. Taiwan Veterinary Journal 36(4):305-314.

21.     Yang SF, Yang HL, Hsiao SH, Lin PC, Cheing BH, Tsai HP, Fan CL, Wang WL, Chang CC, Liang SL. 2010. Case Report: Percutaneous transvenous coil embolization of an extrahepatic portosystemic shunt in a dog. Taiwan Veterinary Journal 36(2):107-114.

22.     Chen PC, Pang VF, Hsiao SH, Chang TC, Chang CC, Chang CH, Wu JC, Jeng CR. 2010. Detection of hepatitis E virus (HEV) infection in pigs, zoo animals, and environmental rodents in Taiwan. Taiwan Veterinary Journal 36(2):124-131.

23.     Tsai YC, Jeng CR, Hsiao SH, Chang HW, Liu JJ, Chang CC, Lin CM, Chia MY, Pang VF. 2010. Porcine circovirus type 2 (PCV2) induces cell proliferation, fusion, and chemokine expression in swine monocytic cells in vitro. Veterinary Research 41(5):60 (SCI) (IF:3.765, 1/145,2010)

24.     Ma WJ, Chen QL, Chang CC. 2010. Investigation of antibody performance and presence of viral rna before and after vaccination of classical swine fever vaccine strain in taiwan pig farms. Taiwan Veterinary Journal 36(1):45-54.

25.     L DY, Zheng ZJ, Jiang MY, Tee KY, Chiou HY, Tsai HP, Tseng YS, Lin HC, Chang CC, Lai JM, Wu JT. 2010. Case Report: Mediastinal b-cell lymphoma in a dog. Taiwan Veterinary Journal 36(1): 67-72.

26.     Meng T, Jia Q, Liu S, Karuppannan AK, Chang CC, Kwang J. 2010. Characterization and epitope mapping of monoclonal antibodies recognizing N-terminus of Rep of porcine circovirus type 2. Journal of Virological Methods 165: 222-229. (SCI) (IF:1.746, 41/66, 2018)

27.     Chang CC, Yoon KJ, Zimmerman JJ. 2009. Evidence that persistent porcine reproductive and respiratory syndrome virus infection in pigs does not require significant genetic change in open reading frame 5. Journal of Swine Health and Production 17(6):318–324. (SCI) (IF: 0.719,44/126, 2002)

28.     Lin CM, Jeng CR, Hsiao SH, Chang CC, Liu CH, Tsai YC, Chia MY, and Pang VF. 2009. Development and evaluation of an indirect in situ polymerase chain reaction for the detection of porcine circovirus type 2 in formalin-fixed and paraffin-embedded tissue specimens. Veterinary Microbiology 138:225-234. (SCI) (IF: 2.370, 5/135, 2008)

29.     Yu CH, Hsiao SH, Chen CY, Chang CC. 2008. Effect of azaperone on plasma cortisol and stress-related gene expression in the hypothalamus-pituitary-adrenal axis in co-mingling weaned pigs. Taiwan Veterinary Journal 34(3):177-183.

30.     Yu CY, Liu YW, Chou SJ, Chao MR, Weng MB, Tsay JG, Chiu CH, Wu CC, Lin TL, Chang CC, Chu CS. 2008. Genomic diversity and molecular differentiation of Riemerella anatipestifer associated with eight outbreaks in five farms. Avian Pathology 37(3): 273-279. (SCI) (IF: 1.809, 12/129, 2008)

31.     Chang HW, Jeng CR, Lin CM, Liu JJ, Chang CC, Tsai YC, Chia MY, and Pang VF. 2007. The involvement of Fas/FasL interaction in porcine circovirus type 2 and porcine reproductive and respiratory syndrome virus co-inoculation-associated lymphocyte apoptosis in vitro. Veterinary Microbiology 122(1-2):72-82. (SCI) (IF: 2.370, 5/135, 2008)

32.     Chang HW, Jeng CR, Liu JJ, Lin TL, Chang CC, Chia MY, Tsai YC, Pang VF. 2005. Reduction of porcine reproductive and respiratory syndrome virus (PRRSV) infection in swine alveolar macrophages by porcine circovirus 2 (PCV2)-induced interferon-alpha. Veterinary Microbiology 108(3-4):167-177.  (SCI) (IF: 2.370, 5/135, 2008)

33.     Cha SH, Chang CC, Yoon KJ. 2004. Instability of the restriction fragment length polymorphism pattern of open reading frame of porcine reproductive and respiratory syndrome virus during sequential pig-to-pig passages. Journal of Clinical Microbiology 42(10):4462-4467. (SCI) (IF:3.439, 20/84, 2004)

34.     Hermann JR, Honeyman MS, Zimmerman JJ, Thacker BJ, Holden PJ, Chang CC. 2003. Effect of dietary Echinacea purpurea on viremia and performance in porcine reproductive and respiratory syndrome virus-infected nursery pigs. Journal of Animal Science 81:2139-2144. (SCI) (IF:1.563, 3/41, 2003)

35.     Hermann JR, Honeyman MS, Holden PJ, Zimmerman JJ, Thacker BJ, Chang CC. 2002. Effects of dietary Echinacea purpurea on PRRSV-infected nursery pigs. Journal of Animal Science Sep;81(9):2139-2144. (SCI) (IF: 1.576,2/42, 2002)

36.     Chang CC, Yoon KJ, Zimmerman JJ, Harmon KM, Dixon PM, Dvorak CMT, Murtaugh MP. 2002. Evolution of porcine reproductive and respiratory syndrome virus during sequential passages in pigs. Journal of Virology 76(10): 4750-4763. (SCI) (IF:5.241, 3/24, 2002)

37.     Horter DC, Pogranichniy RC, Chang CC, Evan R, Yoon KJ, Zimmerman JJ. 2002 Characterization of the carrier state in porcine reproductive and respiratory syndrome virus infection. Veterinary Microbiology 2315: 1-16. (SCI) (IF:1.727, 7/129, 2002)

38.     Yoon KJ, Chang CC, Zimmerman JJ, Harmon KM. 2001. Genetic and antigenic stability of PRRS virus in persistently infected pigs: clinical and experimental prospective. Advances in Experimental Medicine and Biology 494: 25-30. (SCI) (IF:2.126, 30/87, 2018)

39.     Yoon KJ, Chang CC, Zimmerman JJ, Harmon KM. 2001. Field and experimental assessment of PRRSV evolution. 2000 ISU Swine Research Report, p 182-184.

40.     Horter D, Chang CC, Pogranichnyy R, Zimmerman JJ, Yoon KJ. 2001. Persistence of porcine reproductive and respiratory syndrome virus in pigs. Advances in Experimental Medicine and Biology 494: 91-94. (SCI) (IF:2.126, 30/87, 2018)

41.     Wagstrom EA, Chang CC, Yoon KJ, Zimmerman JJ. 2001. Shedding of porcine reproductive and respiratory syndrome (PRRS) virus in mammary secretions of sows. American Journal of Veterinary Research 62:1876-1880. (SCI) (IF:1.040, 25/128, 2001)

42.     Horter DC, Chang CC, Pogranichnyy R, Yoon KJ, Zimmerman JJ. 2000. Persistence of PRRS virus in nursery pigs. 1999 ISU Swine Research Report, p 187.

43.     Yoon KJ, Zimmerman JJ, Chang CC, Cancel-Tredo S CT, McGinley MJ. 1999. Effect of challenge dose and route on porcine reproductive and respiratory syndrome virus (PRRSV) infection in young swine. Veterinary Research 30: 629-638. (SCI) (IF:0.941, 24/129, 1999)

44.     Wagstrom EA, Chang CC, Yoon KJ, Zimmerman JJ. 1998. Shedding of PRRS virus in milk and colostrum. 1997 ISU Swine Research Report, p 161.

45.     Lee KH, Jeng CR, Pang VF, Chang CC, Cheng IC, Chung WB, Chueh LL. 1998. Detection of porcine reproductive and respiratory syndrome virus by in situ hybridization. Taiwan Veterinary Journal 24:16-23.

46.     Yoon KJ, Zimmerman JJ, Chang CC, Reitz P, McGinley M. 1997. Effect of challenge dose and route on transmission of PRRS virus infection. 1996 ISU Swine Research Report, pp 173-175.

47.     Pang VF, Chang CC, Liu KW. 1994. Application of MTT colormetric assay to measure cell proliferation and viability for swine lymphocytes and macrophages. Taiwan Veterinary Journal 20(1):17-26.

48.     鍾文彬、吳大中、林敏雯、黃瓊儀、張志成、張文發、楊平政。 1997. 臺灣地區豬繁殖與呼吸道症候群Ⅲ. 流行病學調查。 Taiwan Veterinary Journal 23(1): 45-50.

49.     Pang VF, Chang CC, Chang WF. 1993. Concurrent gastric and hepatic amebiasis in a dusky leaf monkey (Presbytis obscurus). Journal of Zoo and Wildlife Medicine. 24(2):204-207. (SCI) (IF:0.524, 103/141, 2018)

50.     龐飛、李家豪、闕玲玲、劉振軒、鄭穹翔、邱慧英、張志成、傅瀅濱、張志華、李淑惠、陳美英、蕭終融、張照夫、季昭華、鄭謙仁。 2002. 以聚合酶鏈鎖反應由福馬林固定、石蠟包埋組織進行野生動物分枝桿菌感染之診斷。Taiwan Veterinary Journal 28: 80-87.

51.     蕭世烜、鄭謙仁、張志成、闕玲玲、鄭益謙、楊平政、龐飛。 March 1999. 基因工程產製豬白血球中介質II 對豬隻接種豬生殖與呼吸綜合症死毒免疫效力的影響。 Taiwan Veterinary Journal 25(1):23-33.

52.     季昭華、邱慧英、張志成、陳德勤、龐飛。 1994. Case Report: Malignant mixed mammary tumor in a tiger (Panthera tig-ris) Taiwan Veterinary Journal 20(4):395-401.

53.     Pang VF, Chiou HI, Chang CC. December 1994. Case Report: Mammary gland adenocarcinoma in a lion. Taiwan Veterinary Journal 20(4):312-318.

54.     張志成、龐飛。 1994. Oesophagostomiasis in black gibbon(Hylobates concolorr) and Orangutan(Pongo Pygmaeus) Taiwan Veterinary Journal 20(4):357-361.

55.     張志成、鍾文彬、林敏雯、楊平政、翁仲男、張文發、邱雲棕、劉振軒、朱瑞民。1993. 臺灣地區豬繁殖與呼吸道症候群II. 以無特定病原豬人工接種豬繁殖與呼吸道症候群病毒。 Taiwan Veterinary Journal 19(4):277-284.

56.     張志成、鍾文彬、林敏雯、楊平政、翁仲男、邱雲棕、張文發、朱瑞民。 1993. 臺灣地區豬繁殖與呼吸道症候群I. 病毒分離。Taiwan Veterinary Journal 19(4):268-276.

專書著作

1.        Chang CC. 2019. Viral Disease: Bunyaviruses. DISEASES OF SWINE 11^th. Publisher: Wiley Blackwell/ Publication date (print): 2019-05/ ISBN (print): 978-1-119-35085-9/ ISBN (ebook): 978-1-119-35090-3 (2019-03).

2.        Chang CC. 2012. Viral Disease: Bunyaviruses. DISEASES OF SWINE 10^th. Publisher: Wiley Blackwell/ Publication date (print): 2012-01/ ISBN (print): 978-0-8138-2267-9/2012.

3.        Chang CC. 2001. Evolution of porcine reproductive and respiratory syndrome virus (PRRSV) during sequential pig passages. PhD Dissertation, Iowa State University, USA

4.        楊平政、張志成、朱瑞民 合著。 1996. 豬病診療。台灣養豬科學研究所出版，ISBN 957-9069-01-08, Page 1-170.

5.        張志成、劉振軒、劉錫光 合著。 1994. 台灣野生動物疾病圖譜。台灣養豬科學研究所出版，ISBN 957-9069-16-6, page 1-134.

6.        張志成。 1992.  Effects of low-level aflatoxin on the immune function and growth performance of swine.

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