國立嘉義大學

吳青芬 Wu, Ching Fen

助理教授

最高學歷：德國美茵茲大學（Johannes Gutenberg-Universität Mainz）藥學暨生物化學研究所博士

MAIL：cfwu@mail.ncyu.edu.tw

電話：05-2732960

傳真：05-2732917

簡要經歷

國立嘉義大學獸醫學系助理教授 (2019/08迄今

財團法人農業科技研究院動物科技研究所研究員

財團法人國家衛生研究院蚊媒病中心博士後研究員

高雄醫學大學醫學院傳染病及癌症研究中心博士後研究員

行政院國家科學委員會與德國學術交流總署（NSC/DAAD）博士班研究生赴德研究訪問三明治計畫

研究興趣

天然物分子藥理、實驗室診斷檢測開發

主要教授課程

獸醫臨床病理學及實習、獸醫藥理學、獸醫毒理學、營養疾病學、動物福利學、獸醫免疫學、獸醫細菌學

學術發表

期刊論文:

1. Lo DY, Kuo HC, Twu NC, Wu CF*. Case report: Enterococcus hirae Infection in Suckling Pigs. Taiwan Vet. J. 2022 May; 47(3). DOI: 10.1142/S1682648522500032.

2. Lo DY, Yeh TL, Kuo HC, Wu CF*. Development of Multilocus Sequence Typing (MLST) of Actinobacillus pleuropneumniae. Taiwan Vet. J. 2022 May; 47(3). DOI: 10.1142/S16826485 22720015.

3. Chang GR, Liu HY, Yang WC, Wang CM, Wu CF, Lin JW, Lin WL, Wang YC, Lin TC, Liao HJ, Hou PH, Chan CH, Lin CF. Clozapine worsens glucose intolerance, nonalcoholic fatty liver disease, kidney damage and retinal injury and increases renal reactive oxygen species production and chromium loss in obese mice.    Int. J. Mol. Sci. 2021, 22:6680.    

3. Chang GR, Hsieh WT, Chou LS, Lin CS, Wu CF, Lin JW, Lin WL, Lin TC, Liao HJ, Kao CY, Lin CF. Curcumin improved glucose intolerance, renal injury, and nonalcoholic fatty liver disease and decreased chromium loss through urine in obese mice.   Processes. 2021, 9: 1132.

4. Wu CF, Chen CH, Wu CY, Lin CS, Su YC, Wu CF, Tsai HP, Fan PS, Yeh CH, Yang WC, Chang GR. Quinolone and organophosphorus insecticide residues in bivalves and their associated risks in Taiwan . Molecules. 2020, 25: 3636.

5. Chang CP, Hou PH, Yang WC, Wu CF, Chang CC, Tsai MY, Tsai HP, Lin CT, Xue YJ, Wang JH, Chang GR. Analytical detection of sulfonamides and organophosphorus insecticide residues in fish in Taiwan. Molecules. 2020, 25: 1501.

6. Chang KC, Chou HY, Chen MY, Wu CF, Chen CC, Hung SW. Investigation of folate and folic acid metabolite by validated microbiological methods and LC-MS/MS: quantification in chicken eggs.    Biomed. J. Sci. & Tech. Res. 2019, 17: 12498-12501.

7. Fang CC*, Wu CF*, Liao YJ, Huang SF, Chen M, Chen YM. AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damage. Sci. Rep., 2018, 8:13802. (*:equal contribution)

8. Hong C, Cao J, Wu CF, Kadioglu O, Schüffler A, Kauhl U, Opatz T, Thines E, Efferth T. The Chinese herbal formula Free and Easy Wanderer ameliorates oxidative stress through Keap1-Nrf2/HO-1 pathway. Sci. Rep. 2017, 7:11551.

9. Hong C, Schüffler A, Kauhl U, Cao J, Wu CF, Opatz T, Thines E, Efferth T. Identification of NF-κB as determinant of posttraumatic stress disorder and its inhibition by the Chinese herbal remedy Free and Easy Wanderer. Front. Pharmacol.2017, 8:181.

10. Seo EJ, Wu CF, Ali Z, Wang YH, Khan SI, Walker LA, Khan IA, Efferth T. Both Phenolic and Non-phenolic Green Tea Fractions Inhibit Migration of Cancer Cells. Front. Pharmacol. 2016, 7:398.

11. Efferth T, Banerjee M, Paul N, Abdelfatah S, Arend J, Elhassan G, Hamdoun S, Hamm R, Hong C, Kadioglu O, Naß J, Ochwangi D, Ooko E, Ozenver N, Saeed M, Schneider M, Seo EJ, Wu CF, Yan G, Zeino M, Zhao Q, Abu-Darwish M, Andersch K, Alexie G, Bessarab D, Bhakta-Guha D, Bolzani V, Dapat E, Donenko F, Efferth M, Greten H, Gunatilaka L, Hussein A, Karadeniz A, Khalid H, Kuete V, Lee IS, Liu L, Midiwo J, Mora R, Nakagawa H, Ngassapa O, Noysang C, Omosa L, Roland FH, Shahat A, Saab A, Saeed E, Shan L, Titinchi S. Biopiracy of natural products and good bioprospecting practice. Phytomedicine. 2016, 23: 166-173.

12. Wu CF, Seo EJ, Klauck SM, Efferth T. Cryptotanshinone deregulates unfolded protein response and eukaryotic initiation factor signaling in acute lymphoblastic cells. Phytomedicine 2016, 23: 174-180.

13. Wu CF, Bohnert S, Thines E, Efferth T. Cytotoxicity of the root extract of Salvia miltiorrhiza against multidrug-resistance cancer cells. Am. J. Chin. Med. 2016, 44: 871-894.

14. Wu CF, Karioti A, Rohr D, Bilia AR, Efferth T. Production of rosmarinic acid and salvianolic acid B from callus culture of Salvia miltiorrhiza with cytotoxicity towards acute lymphoblastic leukemia cells. Food Chem. 2016, 201: 292-297.

15. Wu CF, Klauck SM, Efferth T. Anticancer activity of cryptotanshinone on acute lymphoblastic leukemia cells. Arch. Toxicol. 2016, 90: 2275-2286.

16. Wu CF, Hong C, Klauck SM, Lin YL, Efferth T. Molecular mechanisms of rosmarinic acid in acute lymphoblastic leukemia cells. J. Ethanolpharmacol. 2015, 176:55-68.

17. Wu CF, Efferth T. Miltirone induces G2/M cell cycle arrest and apoptosis in CCRF-CEM acute lymphoblastic leukemia cells. J. Nat. Prod. 2015, 78: 1339-1347.

18. Dörsam B,Wu CF,, Efferth T, Kaina B, Fahrer J. The eucalyptus oil ingredient 1,8-cineol induces oxidative DNA damage. Arch. Toxicol. 2015, 89: 797-805.

19. Hamm R, Chen YR, Seo EJ, Zeino M, Wu CF, Müller R, Yang NS, Efferth T. Induction of cholesterol biosynthesis by archazolid B in T24 bladder cancer cells. Biochem. Pharmacol. 2014, 91:18-30.

20. Wu CFLin YL, Huang YT. Hepatitis C virus core protein stimulates fibrogenesis in hepatic stellate cells involving the obese receptor. J. Cell. Biochem. 2013, 114: 541-550

21. Lin YL, Wu CF, Huang, YT. Effects of Rhubarb on migration of rat hepatic stellate cells.J. Gastroenterol. Hepatol. 2009, 24: 453-61

22. Lin YL, Wu CF, Huang, YT. Phenols from the roots of Rheum palmatumattenuates chemotaxis in rat hepatic stellate cells.Planta Med. 2008, 74: 1246-52.

23. Hsu YC, Chiu YT, Cheng CC, Wu CF, Lin YL, Huang, YT. 2005. Antifibrotic effects of tetrandrine on hepatic stellate cells and rats with liver fibrosis. J. Gastroenterol. Hepatol, 2007, 22: 99-111.

24. Hsu YC, Chiu YT, Lee CY, Wu CF, Huang, YT. Antifibrotic effects of tetrandrine on bile duct ligated rats. Can. J. Physiol. Pharmacol. 2006, 84: 967-976.

專書著作:

1. Wu CF, Efferth T. (2017) Anticancer activity of Salvia miltiorrhiza secondary metabolites, in Salvia Biotechnology (eds V. Georgiev and A. Pavlov), Springer International Publishing. pp. 179-208. Doi: 10.1007/978-3-319-73900-7_5

2. Seo EJ, Wu CF, Greten HJ, Efferth T. (2015) Epidermal growth factor receptors and downstream signalling pathways as cancer treatment targets for medicinal plants, in Ethnopharmacology (eds M. Heinrich and A. K. Jäger), John Wiley & Sons, Ltd, Chichester, UK. pp.169-178. Doi:10.1002/9781118930717.ch16

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