最高學歷:國立臺灣大學獸醫學系博士(碩士/學士:國立中興大學獸醫學系)
工作經歷:
國立嘉義大學獸醫學系 助理教授(2025/02–迄今)
農業部獸醫研究所/行政院農業委員會家畜衛生試驗所 副研究員/助理研究員(2008/11–2025/01)
國際專業經歷:
世界動物衛生組織(WOAH)狂犬病參考實驗室專家(履職期間:2024/06–2025/01)
WOAH亞太區域代表處專家智庫「Vaccine and Vaccination」領域專家(2021年由會員國提名)
主要教授課程:獸醫組織學、禽病學、豬病學、獸醫病毒學、獸醫疫苗學
研究興趣:家禽疾病與禽流感、傳染性疾病風險分析與早期預警、人工智慧於動物健康之應用、動物疫苗;其他過往專長及專業經驗領域亦歡迎洽詢合作。
專長/專業經驗簡介:
家禽疾病與現場防疫
家禽疾病診斷、產業疾病結構議題、現場生物安全與疾病防治。
狂犬病與國際合作
狂犬病診斷、病原性試驗、口服疫苗研析及國際合作;具狂犬病中和抗體檢測(FAVN)技術建立、ISO/IEC 17025 品質系統建立、犬貓國際移動狂犬病血清學檢測與取得歐盟及日本認可之實務經驗,以及國際能力試驗建立、規劃與辦理經驗。
動物疫苗
動物疫苗 GMP 生產與商品化研發(包括符合歐洲藥典規格之家禽活毒疫苗、基因改造疫苗及次單位疫苗);具 PIC/S GMP 疫苗生產設施工程設計規劃經驗。
獸醫病毒學與分子生物技術
病毒分離、培養、鑑定、純化及病原性/抗原性分析;反向遺傳學重組病毒構築、分子選殖、原核/真核蛋白表現與純化,及單株抗體研製。
實驗室生物安全與動物試驗
BSL-2 實驗室及動物試驗設施管理、實驗室生物安全、多物種動物試驗經驗(雞/鼬獾/白鼻心/牛/小鼠/兔),以及多項國內外能力試驗/實驗室間比對參加經驗(狂犬病/非洲豬瘟/豬瘟)。
疫苗研發商品化成果:
1. 第七基因型新城病弱毒活毒疫苗完成可專利性分析。
2. 豬瘟組織培養疫苗量產技術共同開發者;相關技術於 2020 年技術移轉予國內三家動物用疫苗廠。
3. 鴨病毒性肝炎及水禽小病毒卵黃抗體生物製劑共同研發者;相關技術於 2020 年技術移轉予國內一家動物用疫苗廠。
專業培訓:行政院農業委員會農業菁英培訓計畫:赴法國南錫WOAH/WHO/EU狂犬病參考實驗室接受專業訓練三個月(2017)
研究成果列表:
期刊論文
1. Chang YC, Hsu AP, Tseng CH, Shih YH, Hu SC, Chang YC, et al. Rabies surveillance education and training report in Taiwan. Exp. Rep AHRI. 2022;56:17-30.
2. Hsu AP, Tseng CH, Shih YH, Tsai KJ, Lu YT, Chou CH, et al. Pathogenicity of Taiwan ferret badger rabies virus in rodents. Taiwan Vet J. 2018;44:133-139.
3. Hsu AP, Tseng CH, Lu YT, Shih YH, Chou CH, Chen RS, et al. Development of a quantitative real-time RT-PCR assay for detecting Taiwan ferret badger rabies virus in ear tissue of ferret badgers and mice. J Vet Med Sci. 2018;80(6):1012-1019.
4. Hsu AP, Tseng CH, Barrat J, Lee SH, Shih YH, Wasniewski M, et al. Safety, efficacy and immunogenicity evaluation of the SAG2 oral rabies vaccine in Formosan ferret badgers. PLoS One. 2017;12(10): e0184831.
5. Hsu AP, Lin YJ, Lee YL, Tseng CH, Huang TS. Development of Bovine Ephemeral Fever G Protein Subunit Vaccines. Exp. Rep AHRI. 2013;48:29-38.
6. Lin KH, Lin CF, Chiou SS, Hsu AP, Lee MS, Chang CC, et al. Application of purified recombinant antigenic spike fragments to the diagnosis of avian infectious bronchitis virus infection. Appl Microbiol Biotechnol. 2012 Jul;95(1):233-42.
7. Lin KH, Hsu AP, Shien JH, Chang TJ, Liao JW, Chen JR, et al. Avian reovirus sigma C enhances the mucosal and systemic immune responses elicited by antigen-conjugated lactic acid bacteria. Vaccine. 2012 Jul 13;30(33):5019-29.
研討會論文
1. Hsu AP, Chang YC, Cheng CH, Lin CC, Tseng CH, Shih YH, et al. Surveillance of zoonotic infectious diseases in wildlife – the advance of Taiwanese rabies surveillance based on WOAH twinning project for rabies. 35th Annual Conference of the International Society for Environmental Epidemiology. Kaohsiung, Taiwan (Sep 2023).
2. Hsu AP, Tseng CH, Shih YH, Lu CH, Chou YS, Chen CH, et al. New generation recombinant vaccine development: from idea to the product (using Newcastle virus vaccine of genotype VII as the model). FFTC-TLRI Symposium on Innovation and Application of Animal Vaccines and Health-Promotion Feed Additives for Antibiotic-Free Era in Livestock Industry. Taipei/Virtual (Nov 2021).
3. Hsu AP, Chen H, Lu YT, Chou YS, Chang JY, Shih YH, et al. Development of a Newcastle disease live vaccine of genotype VII and the application of vector vaccine technologies. XIII International Conference on Vaccines and Vaccination (ICVV 2019). Istanbul, Turkey (Dec 2019).
4. Hsu AP, Lee SY, Tseng CH, Shih YH, Cliquet F, Robardet E, et al. Implementation summary of OIE Twinning Project for Rabies. Rabies in the Americas (RITA 30). Kansas City, USA (Oct 2019).
5. Hsu AP, Lu YT, Tseng CH, Lee SY, Shih YH. Pathogenicity investigation of Taiwan ferret badger rabies virus on Gem-faced civets. Rabies in the Americas (RITA 30). Kansas City, USA (Oct 2019).
6. Hsu AP. The goal of our twinning project (including introducing the Asian proficiency test). 2018 Launching Meeting of OIE Twinning Project for Rabies between Anses-Nancy and AHRI. Taipei, Taiwan (Oct 2018).
7. Hsu AP, Chang CC, Shih YH, Lin CT, Tsai JH, Yeh SR, et al. The antibody responses of Formosan ferret badgers after receiving rabies inactivated vaccines. Rabies serology meeting 2017. Budapest, Hungary (June 2017).
8.Hsu AP, Shih YH, Lu YT, Chen H, Chen RS, Tu WJ, et al. The development of Newcastle disease vector vaccines. Conference of Chinese Society of Veterinary Sciences. Taichung, Taiwan (Nov 2016).
9. Hsu AP, Tseng CH, Shih YH, Chou CH, Cliquet F, Tsai HJ, et al. Replication properties of Taiwan ferret badger rabies virus in mice. Rabies in the Americas (RITA) 26th International Meeting. Fort Collins, Colorado, USA (Oct 2015).
10. Hsu AP, Shih YH, Liu HF, Lin YJ, Lee SH, Tseng CH, Tsai HJ. Sequence Analysis of Ferret Badger Rabies Virus from Taiwan Outbreak in 2013. IUMS. Montreal, Canada. (Aug 2014).