國立嘉義大學入口網獸醫學系專任教師張耿瑞教授

專長：動物藥理學、動物生理學、人類疾病動物模式研究、分析毒理學、食品安全研究

最高學歷：國立中興大學獸醫學研究所博士
電子信箱：grchang@mail.ncyu.edu.tw
電話：05-2732946

簡要經歷：
國立嘉義大學獸醫學系教授 (2021/8-現職)
國立嘉義大學獸醫學系副教授 (2018/8-2021/7)
國立嘉義大學獸醫學系助理教授(2016/8-2018/7)
日本北海道大學獸醫學系獸醫環境科學講座毒理學研究室訪問學者(2013/8-2013/9)
行政院農業委員會農業藥物毒物試驗所助理研究員 (2010/11 – 2016/7)
苗栗縣政府農業處公職獸醫師 (2005/9 – 2010/11)
臺中市動物保護防疫所公職獸醫師 (2005/8)

主要教授課程：獸醫藥理學、實驗動物學、獸醫中藥學、中獸醫方劑學

研究興趣：代謝症候群之藥物和分子調控機制、人類免疫抑制和腫瘤之實驗動物模式、野生動物繁殖內分泌生理學、動物基質中藥物及毒物殘留分析檢測、中獸藥之基礎研究及應用

媒體報導
2020-2022:
[買酵素送台南鳳梨吃進新鮮喝進健康絕對值回票價] 2020/04/21 勁報
[「買酵素贈鳳梨」，臺南市府偕大漢酵素做公益] 2020/05/19 工商時報
[嘉大攜手林口長庚醫院發現治療肺癌新藥] 2021/05/11 自由時報
[嘉大師生團隊攜手林口長庚紀念醫院發現治療肺癌新藥] 2021/05/11 新浪新聞
[抗肺癌新藥物嘉大與林口長庚紀念醫院研發有成] 2021/05/11 今傳媒
[嘉大攜手林口長庚醫院發現治療肺癌新契機] 2021/05/11 台灣捷報
[攜手林口長庚發現治肺癌新藥嘉大國際期刊登載受矚目] 2021/05/11 台灣好報
[杜絕犬貓狂犬病嘉大USR無償參與疫苗注射] 2021/09/02 勁報
[懸賞50萬找愛貓引「暴動」律師提醒法律後果：別亂開價] 2022/01/16 聯合報
[致死率比新冠肺炎高！今年4例鼬獾狂犬病嘉縣佔2例急打疫苗防堵] 2022/06/10 蘋果新聞網
[嘉縣檢出2起狂犬病家畜所趕在梅雨季前完成疫苗注射] 2022/06/10 中時新聞網
[嘉縣2例鼬獾狂犬病阿里山各部落完成犬貓預防注射] 2022/06/10 聯合新聞網
[嘉大攜手林口長庚突破大細胞肺癌治療困境] 2022/06/17 自由健康網
[嘉大、長庚攜手突破大細胞肺癌治療困境] 2022/06/17 聯合新聞網
[突破大細胞肺癌治療困境嘉大攜手林口長庚為臨床醫學盡心力] 2022/06/17 新浪新聞
[嘉大獸醫學系張耿瑞副教授團隊攜手林口長庚醫院突破大細胞肺癌治療困境增加患者存活率並抑制大細胞肺癌轉移] 2022/06/17 台灣華報
[嘉大攜手林口長庚突破大細胞肺癌治療困境為臨床醫學盡心力] 2022/06/17 PChome新聞
[嘉大攜手林口長庚突破大細胞肺癌治療困境] 2022/06/17 大紀元新聞網
[突破大細胞肺癌治療困境嘉大攜手林口長庚為臨床醫學盡心力] 2022/06/17 TNN台灣地方新聞
[大細胞肺癌治療困境有解] 2022/06/17 台灣新生報
[登國際期刊台突破大細胞肺癌治療困境] 2022/06/18 中華日報
[嘉大攜手林口長庚突破大細胞肺癌治療受國際高度重視] 2022/06/18 觀傳媒
[花青素能抑制大細胞肺癌腫瘤增長嘉大攜手長庚突破治療困境] 2022/06/19 蘋果新聞網
[嘉義防堵狂犬病入侵寵物健診打預防針] 2022/08/29 中時新聞網

論文發表
-Selected Publications (2018-2022)-
1. Wu CF, Wu CY, Lin CF, Liu YW, Lin TC, Liao HJ, Chang GR. The anticancer effects of cyanidin 3-O-glucoside combined with 5-fluorouracil on lung large-cell carcinoma in nude mice. Biomedicine & pharmacotherapy 2022; 151: 113128. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 26/279, 9.31%; IF = 7.419)
2. Chang GR, Lin WL, Lin TC, Liao HJ, Lu YW. The ameliorative effects of saikosaponin in thioacetamide-induced liver injury and non-alcoholic fatty liver disease in mice. International Journal of Molecular Sciences 2021; 22: 189. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 69/296, 23.31%; IF = 6.208)
3. Chang GR, Hou PH, Wang CM, Lin JW, Lin WL, Lin TC, Liao HJ, Chan CH, Wang YC. Imipramine accelerates nonalcoholic fatty liver disease, renal impairment, diabetic retinopathy, insulin resistance and urinary chromium loss in obese mice. Veterinary Sciences 2021; 8: 189. (SCI; Veterinary Sciences: Rank Factor = 37/144, 25.69%; IF = 2.518)
4. Wang JH, Chang CP, Chang CC, Wang CM, Lin CF, Lin JW, Lin WL, Liao HY, Kao CY, Fan PS, Yang WC, Chang GR. Analysis of persistent organochlorine pesticides in shellfish and their risk assessment from aquafarms in Taiwan. Marine Pollution Bulletin 2021; 172: 112811. (SCI; MARINE & FRESHWATER BIOLOGY: Rank Factor = 2/113, 1.77%; IF = 7.001)
5. Chang GR, Kuo CY, Tsai MY, Lin WL, Lin TC, Liao HJ, Chen CH, Wang YC. Anti-cancer effects of zotarolimus combined with 5-fluorouracil treatment in HCT-116 colorectal cancer-bearing BALB/c nude mice. Molecules 2021; 26: 4683. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 65/179, 36.31%; IF = 4.927)
6. Chang GR, Hsieh WT, Chou LS, Lin CS, Wu CF, Lin JW, Lin WL, Lin TC, Liao HJ, Kao CY Lin CF. Curcumin improved glucose intolerance, renal injury, and nonalcoholic fatty liver disease and decreased chromium loss through urine in obese mice. Processes 2021; 9: 1132. (SCI; ENGINEERING & CHEMICAL: Rank Factor = 69/142, 48.59%; IF = 3.352)
7. Chang GR, Liu HY, Yang WC, Wang CM, Wu CF, Lin JW, Lin WL, Wang YC, Lin TC, Liao HJ, Hou PH, Chan CH, Lin CF. Clozapine worsens glucose intolerance, nonalcoholic fatty liver disease, kidney damage and retinal injury and increases renal reactive oxygen species production and chromium loss in obese mice. International Journal of Molecular Sciences 2021; 22: 6680. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 69/296, 23.31%; IF = 6.208)
8. Wu CF, Wu CY, Chiou RYY, Yang WC, Lin CF, Wang CM, Hou PH, Lin TC, Kuo CY, Chang GR. The anti-cancer effects of a zotarolimus and 5-fluorouracil combination treatment on A549 cell-derived tumors in BALB/c nude mice. International Journal of Molecular Sciences 2021; 22: 4562. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 69/296, 23.31%; IF = 6.208)
9. Tsai MY, Yang WC, Lin CF, Wang CM, Liu HY, Lin CS, Lin JW, Lin WL, Lin TC, Fan PS, Hung KH, Lu YW, Chang GR. The ameliorative effects of fucoidan in thioacetaide-induced liver injury in mice. Molecules 2021; 26: 1937. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 65/179, 36.31%; IF = 4.927)
10. Chang GR, Hou PH, Yang WC, Wang CM, Fan PS, Liao HJ, Chen TP. Doxepin exacerbates renal damage, glucose intolerance, nonalcoholic fatty liver disease and urinary chromium loss in obese mice. Pharmaceuticals 2021; 14: 267. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 69/279, 24.73%; IF = 5.215; first author and corresponding author)
11. Chang GR, Hou PH, Wang CM, Wu CF, Su HK, Liao HJ, Chen TP. Chronic everolimus treatment of high fat diet mice leads to a reduction in obesity but impaired glucose tolerance. Pharmacology Research & Perspectives 2021; 9: e00732. (SCI; PHARMACOLOGY & PHARMACY: Rank Factor = 181/279, 64.87%; IF = 2.963; first author and corresponding author)
12. Tsai HP, Hou PH, Mao FC, Chang CC, Yang WC, Wu CF, Liao HJ, Lin TC, Chou LS, Hsiao LW, Chang GR. Risperidone exacerbates glucose intolerance, nonalcoholic fatty liver disease, and renal impairment in obese mice. International Journal of Molecular Sciences 2021; 22: 49. (SCI; BIOCHEMISTRY & MOLECULAR BIOLOGY: Rank Factor = 65/179, 36.31%; IF = 4.927)
13. Hseu YC, Chiang YC, Gowrisankar YV, Lin KY, Huang ST, Shrestha S, Chang GR, Yang HL. The in vitro and in vivo anticancer properties of chalcone flavokawain b through induction of ros-mediated apoptotic and autophagic cell death in human melanoma cells. Cancers. 2020; 12: 2936. (SCI; ONCOLOGY; Rank Factor = 79/317, 24.92%; IF = 6.575; corresponding author)
14. Wu CF, Hou PH, Mao FC, Su YC, Wu CY, Yang WC, Lin CS, Tsai HP, Liao HY, Chang GR. Mirtazapine reduces adipocyte hypertrophy and increases glucose transporter expression in obese mice. Animals 2020; 10: 1423. (SCI; VETERINARY SCIENCES: Rank Factor = 16/144, 11.11%; IF = 3.231)
15. Wu CF, Chen CH, Wu CY, Lin CS, Su YC, Wu CF, Tsai HP, Fan PS, Yeh CH, Yang WC, Chang GR. Quinolone and organophosphorus insecticide residues in bivalves and their associated risks in Taiwan. Molecules 2020; 25: 3636. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor =65/179, 36.31%; IF = 4.927)
16. Chang GR, Hou PH, Chen WK, Lin CT, Tsai HP, Mao FC. Exercise affects blood glucose levels and tissue chromium distribution in high-fat diet-fed C57BL6 mice. Molecules 2020; 25: 1658. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 65/179, 36.31%; IF = 4.927)
17. Chang CP, Hou PH, Yang WC, Wu CF, Chang CC, Tsai MY, Tsai HP, Lin CT, Xue YJ, Wang JH, Chang GR. Analytical detection of sulfonamides and organophosphorus insecticide residues in fish in Taiwan. Molecules 2020; 25: 1501. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 65/179, 36.31%; IF = 4.927)
18. Tsai MY, Ho CH, Chang HY, Yang WC, Lin CF, Lin CT, Xue YJ, Lai JM, Wang JH, Chang GR. Analysis of pollution of phthalates in pork and chicken in Taiwan using liquid chromatography-tandem mass spectrometry and assessment of health risk. Molecules 2019; 24: 3817. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 65/179, 36.31%; IF = 4.927)
19. Tsai MY, Lin CF, Yang WC, Lin CT, Hung KH, Chang GR. Health risk assessment of banned veterinary drugs and quinolone residues in shrimp through liquid chromatography–tandem mass spectrometry. Applied Sciences 2019; 9: 2463. (SCI; CHEMISTRY, MULTIDISCIPLINARY: Rank Factor = 100/179, 55.87%; IF = 2.838)
20. Chang HY, Yang WC, Xue YJ, Tsai MY, Wang JH, Chang GR. Phthalates and organophosphorus insecticide residues in shrimp determined by liquid/gas chromatography–tandem mass spectrometry and a health risk assessment. Marine Pollution Bulletin 2019; 144: 140-145. (SCI; MARINE & FRESHWATER BIOLOGY: Rank Factor = 2/113, 1.77%; IF = 7.001)
21. Hseu YC, Chang GR, Pan JY, Rajendran P, Mathew DC, Li ML, Liao JW, Chen WT, Yang HL. Antrodia camphorata inhibits epithelial-to-mesenchymal transition by targeting multiple pathways in triple-negative breast cancers. Journal of Cellular Physiology 2019; 234: 4125-4139. (SCI; PHYSIOLOGY: Rank Factor = 10/81, 12.34%; IF = 6.513)
22. Hou PH, Chang GR, Chen CP, Lin YL, Chao IS, Shen TT, Mao FC. Long-term administration of olanzapine induces adiposity and increases hepatic fatty acid desaturation protein in female C57BL/6J mice. Iranian Journal of Basic Medical Sciences 2018; 21: 495-501. (SCI; MEDICINE, RESEARCH & EXPERIMENTAL: Rank Factor = 112/139, 80.58%; IF = 2.532)
23. Hou PH, Mao FC, Chang GR, Huang MW, Wang YT, Huang SS. Newly Diagnosed Bipolar Disorder and the Subsequent Risk of Erectile Dysfunction: A Nationwide Cohort Study. Journal of Sexual Medicine 2018; 15: 183-191. (SCI; UROLOGY & NEPHROLOGY: Rank Factor = 39/90, 43.33%; IF = 3.937)
24. Chang GR. Persistent organochlorine pesticides in aquatic environments and fishes in Taiwan and their risk assessment. Environmental Science and Pollution Research 2018; 25: 7699-7708. (SCI; ENVIRONMENTAL SCIENCES: Rank Factor = 107/324, 33.02%; IF = 5.190)

更多研究成果列表